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bone morphogenetic protein 15

Known as: GDF 9 Related Factor, Growth Differentiation Factor 9B, BMP15 
A protein that plays a role in GRANULOSA CELLS where it regulates folliculogenesis. Mutations in the gene for bone morphogenetic protein 15 are… Expand
National Institutes of Health

Related topics

Related topics

22 relations
BMP15 geneBone Morphogenetic Protein GeneCell Differentiation processCell Proliferation Regulatory Process
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Papers overview

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Highly Cited
2005
Highly Cited
2005
Oocytes prevent cumulus cell apoptosis by maintaining a morphogenic paracrine gradient of bone morphogenetic proteins
Paracrine factors secreted by the oocyte regulate a broad range of cumulus cell functions. Characteristically, cumulus cells have… Expand
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Highly Cited
2005
Highly Cited
2005
Bone morphogenetic protein 15 and growth differentiation factor 9 co-operate to regulate granulosa cell function.
The oocyte-secreted polypeptide growth factors, growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15… Expand
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Highly Cited
2004
Highly Cited
2004
Hypergonadotropic ovarian failure associated with an inherited mutation of human bone morphogenetic protein-15 (BMP15) gene.
Hypergonadotropic ovarian failure is a common cause of female infertility. It is a heterogeneous disorder that, in the most… Expand
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Highly Cited
2003
Highly Cited
2003
Osteogenic activity of the fourteen types of human bone morphogenetic proteins (BMPs).
BACKGROUND Bone morphogenic proteins (BMPs) are known to promote osteogenesis, and clinical trials are currently underway to… Expand
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Highly Cited
2003
Highly Cited
2003
Molecular Basis of Bone Morphogenetic Protein-15 Signaling in Granulosa Cells*
Bone morphogenetic protein-15 (BMP-15), an oocyte growth factor belonging to the transforming growth factor-β superfamily, has… Expand
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Highly Cited
2002
Highly Cited
2002
A negative feedback system between oocyte bone morphogenetic protein 15 and granulosa cell kit ligand: Its role in regulating granulosa cell mitosis
Although the existence of a regulatory paracrine feedback system between oocytes and follicular somatic cells has been postulated… Expand
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Highly Cited
2001
Highly Cited
2001
Synergistic roles of bone morphogenetic protein 15 and growth differentiation factor 9 in ovarian function.
Knockout mouse technology has been used over the last decade to define the essential roles of ovarian-expressed genes and uncover… Expand
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Highly Cited
2001
Highly Cited
2001
Bone Morphogenetic Protein-15 Inhibits Follicle-stimulating Hormone (FSH) Action by Suppressing FSH Receptor Expression*
We have recently reported that oocyte-derived bone morphogenetic protein-15 (BMP-15) can directly modulate follicle-stimulating… Expand
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Highly Cited
2000
Highly Cited
2000
Bone Morphogenetic Protein-15
In developing ovarian follicles, the regulation of cell proliferation and differentiation is tightly coordinated. Precisely how… Expand
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Highly Cited
1998
Highly Cited
1998
The bone morphogenetic protein 15 gene is X-linked and expressed in oocytes.
We have taken advantage of the sequence relationships among the bone morphogenetic proteins (BMPs) to identify the mouse Bmp15… Expand
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