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beta selection

The process in which successful recombination of a T cell receptor beta chain into a translatable protein coding sequence leads to rescue from… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2009
2009
Critical Roles of Translationally Controlled Tumor Protein in the Homeostasis and TCR-Mediated Proliferation of Peripheral T Cells1
Translationally controlled tumor protein (TCTP) is expressed throughout T cell development and prominently induced following T… 
2008
2008
Recombinase‐deficient T cell development by selective accumulation of CD3 into lipid rafts
The pre‐T cell receptor (pre‐TCR) promotes the development of thymocytes with productive rearrangement at the TCR β chain locus… 
2007
2007
p16INK4A tumor suppressor gene expression and CD3epsilon deficiency but not pre-TCR deficiency inhibit TAL1-linked T-lineage leukemogenesis.
Inactivation of the CDKN2 genes that encode the p16(INK4A) and p14(ARF) proteins occurs in the majority of human T-cell acute… 
2006
2006
Human alpha beta and gamma delta thymocyte development: TCR gene rearrangements, intracellular TCR beta expression, and gamma delta developmental potential--differences between men and mice.
To evaluate the role of the TCR in the alphabeta/gammadelta lineage choice during human thymocyte development, molecular analyses… 
2006
2006
ShcA Mediates the Dominant Pathway to Extracellular Signal-Regulated Kinase Activation during Early Thymic Development
ABSTRACT During thymic development, the β selection checkpoint is regulated by pre-T-cell receptor-initiated signals. Progression… 
Review
2003
Review
2003
Mechanisms of apoptosis in developing thymocytes as revealed by adenosine deaminase-deficient fetal thymic organ cultures.
2001
2001
The Biological Activity of Natural and Mutant Ptα Alleles
β selection is a major checkpoint in early thymocyte differentiation, mediated by successful expression of the pre-T cell… 
Highly Cited
1998
Highly Cited
1998
TCR Transgenic Mice in Which Usage of Transgenic α- and β-Chains Is Highly Dependent on the Level of Selecting Ligand
We have produced a TCR transgenic mouse that uses a TCR derived from a Th1 clone that is specific for residues 64 to 76 of the… 
1998
1998
Requirement of CD3 Complex–associated Signaling Functions for Expression of Rearranged T Cell Receptor β VDJ Genes in Early Thymic Development
During αβ thymocyte development, the clonotypic αβ–T cell receptor (TCR) is preceded by sequentially expressed immature versions… 
1997
1997
Restoration of thymopoiesis in pT alpha-/- mice by anti-CD3epsilon antibody treatment or with transgenes encoding activated Lck or tailless pT alpha.
Mice deficient for the pre-TCR alpha (pT alpha) chain cannot form a pre-T cell receptor (TCR) and exhibit a severe defect in… 
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