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beta selection

The process in which successful recombination of a T cell receptor beta chain into a translatable protein coding sequence leads to rescue from… 
National Institutes of Health

Papers overview

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2008
2008
Recombinase‐deficient T cell development by selective accumulation of CD3 into lipid rafts
The pre‐T cell receptor (pre‐TCR) promotes the development of thymocytes with productive rearrangement at the TCR β chain locus… 
2006
2006
ShcA Mediates the Dominant Pathway to Extracellular Signal-Regulated Kinase Activation during Early Thymic Development
ABSTRACT During thymic development, the β selection checkpoint is regulated by pre-T-cell receptor-initiated signals. Progression… 
Review
2003
Review
2003
Mechanisms of apoptosis in developing thymocytes as revealed by adenosine deaminase-deficient fetal thymic organ cultures.
2001
2001
Expression and selection of productively rearranged TCR beta VDJ genes are sequentially regulated by CD3 signaling in the development of NK1.1(+) alpha beta T cells.
The generation of thymic NK1.1(+)alpha beta T (NKT) cells involves positive selection of cells enriched for V(alpha)14/V(beta)8… 
2000
2000
Facilitation of ␤ Selection and Modification of Positive Selection in the Thymus of Pd-1–deficient Mice
PD-1 is an immunoglobulin superfamily member bearing an immunoreceptor tyrosine-based inhibitory motif, and disruption of the PD… 
1998
1998
Requirement of CD3 Complex–associated Signaling Functions for Expression of Rearranged T Cell Receptor β VDJ Genes in Early Thymic Development
During αβ thymocyte development, the clonotypic αβ–T cell receptor (TCR) is preceded by sequentially expressed immature versions… 
1997
1997
Restoration of thymopoiesis in pT alpha-/- mice by anti-CD3epsilon antibody treatment or with transgenes encoding activated Lck or tailless pT alpha.
Mice deficient for the pre-TCR alpha (pT alpha) chain cannot form a pre-T cell receptor (TCR) and exhibit a severe defect in… 
1997
1997
Normal junctional diversification of immune receptors in p53-deficient mice.
One of the strategies that the immune system utilizes to generate Ab and TCR diversity is programmed imprecision of coding joint… 
1996
1996
T cells receptor beta-chain repertoires are nonrandomly selected in responses to HLA-DR1.
T cell receptor (TCR) beta-chain usage by HLA-DR1 alloreactive T cell lines was examined to determine whether common TCR gene… 
1996
1996
T cell receptor-gamma, delta-expressing fetal mouse thymocytes are generated without T cell receptor V beta selection.
We investigated whether fetal mouse T cell receptor (TCR) gamma delta cells have been subjected to so-called TCR beta selection… 
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