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beta selection

The process in which successful recombination of a T cell receptor beta chain into a translatable protein coding sequence leads to rescue from… 
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development.
Review
2010
Review
2010
Notch regulation of early thymocyte development.
Highly Cited
2004
Highly Cited
2004
Obligatory Role for Cooperative Signaling by Pre-TCR and Notch during Thymocyte Differentiation1
The first checkpoint during T cell development, known as β selection, requires the successful rearrangement of the TCR-β gene… 
2004
2004
Deranged Early T Cell Development in Immunodeficient Strains of Nonobese Diabetic Mice1
NOD mice exhibit defects in T cell functions that have been postulated to contribute to diabetes susceptibility in this strain… 
Highly Cited
2003
Highly Cited
2003
Critical roles for transcription factor GATA-3 in thymocyte development.
Highly Cited
2000
Highly Cited
2000
The Gtpase Rho Controls a P53-Dependent Survival Checkpoint during Thymopoiesis
During the early stages of thymopoiesis, cell survival is controlled by cytokines that regulate the expression of antiapoptotic… 
Review
1998
Review
1998
Crucial function of the pre‐T‐cell receptor (TCR) in TCRP selection, TCRβ allelic exclusion and αβ versus γδ lineage commitment
Summary: The analysis of T‐cell receptor (TCR) βselection, TCRβ allelic exclusion and TCRβ rearrangement in γδ T cells from… 
Highly Cited
1998
Highly Cited
1998
TCR Transgenic Mice in Which Usage of Transgenic α- and β-Chains Is Highly Dependent on the Level of Selecting Ligand
We have produced a TCR transgenic mouse that uses a TCR derived from a Th1 clone that is specific for residues 64 to 76 of the… 
Highly Cited
1996
Highly Cited
1996
Productive T-cell receptor beta-chain gene rearrangement: coincident regulation of cell cycle and clonality during development in vivo.
Productive gene rearrangement at the T-cell receptor (TCR) beta-chain locus facilitates formation of the "pre-TCR," a molecular… 
Highly Cited
1989
Highly Cited
1989
Failure of T cell receptor V beta negative selection in an athymic environment.
The mature T cell receptor (TCR) repertoire is the result of selection events during T cell development. Previous assessment of… 
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