benzo(a)pyrene diolepoxide I

After treatment with ultraviolet radiation (UV), human fibroblasts that express the HPV type 16 E6 oncoprotein display defects in… (More)

Cancer is a genetic disease and carcinogenesis is the process whereby the relevant genetic alterations are acquired… (More)

The findin«that 7r,8f-dihydroxy-9,10f-oxy-7,8,9,10-tetrahydrobenzo(a)pyrene (BPDE-I) is stabilized against hydrolysis by binding… (More)

Previous spectroscopic studies of the major adduct formed by reaction of (±)-7r,8f-dihydroxy-9f,10f-oxy-7,8,9,10-tetrahydrobenzo… (More)

DNA repair capacity is a system of defenses designed to protect the integrity of the genome. The difficulty in studying DNA… (More)

Cellular detoxification is important for the routine removal of environmental and dietary carcinogens. Glutathione S-transferases… (More)

The objective of this study is to determine whether pentachlorophenol (PCP) alters benzo[a]pyrene (B[a]P)-induced DNA adduct… (More)

The mechanism of differential efficacies of diallyl sulfide (DAS), diallyl disulfide (DADS), diallyl trisulfide (DATS), dipropyl… (More)

The kinetics of the conjugation of glutathione (GSH) with anti-7beta, 8alpha-dihydroxy-9alpha,10alpha-oxy-7,8,9, 10… (More)

We are using an SV40-based shuttle vector, pZ189, to study mechanisms of mutagenesis in mammalian cells. The vector can be… (More)