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benfluron

Known as: 5-(2-dimethylaminoethoxy)-7-oxo-7H-benzo(c)fluorene, benflurone 
National Institutes of Health

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VUFB 13468

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1998
1998
Induction and Inhibition of Cytochrome P450-Catalysed Reduction of Biologically Active Benfluron N-Oxide
Benfluron N-oxide [5-(2-N-oxo-2-N,N'-dimethylaminoethoxy)-7-oxo-7-H-benzo[c]fluorene] is a biologically active substance which… 
1996
1996
Study of the biotransformation of a potential benzo[c]fluorene antineoplastic using high-performance liquid chromatography with high-speed-scanning ultraviolet detection.
1993
1993
9‐Hydroxybenfluron induced inhibition of proliferation and metabolism in hela cells
The highest concentration of 9‐hydroxybenfluron (HBF) tested, namely 4·05 μmol1−1, induced immediate cytotoxic effects which were… 
1993
1993
Expression of disodium cromoglygate 'protective' effects observed during V79 cell proliferation.
1991
1991
Elimination of Benfluron and its Metabolites in the Faeces and Urine of Rats
The study of the biotransformation of the potential cytostatic benfluron has been continued. The elimination of benfluron and of… 
1989
1989
Effect of benfluron metabolites on ATP level in tumor cells.
Changes in ATP levels of both Ehrlich ascites carcinoma and P388 leukemia cells were evaluated after 2 h of incubation in the… 
1988
1988
The mechanism of cytolytic and cytostatic activity of benfluron.
Benfluron at concentrations of 0.26 and 0.52 mumol l-1 inhibited the formation of V79 colonies in a concentration-dependent way… 
1987
1987
Chromatographic and enzymatic evidence for the structure of an oxygenated and reduced metabolite of Benflurone.
1985
1985
Derivatives of benzo(c)fluorene. XVI. Absorption, distribution and elimination of 3H-benflurone, 5-(2-N,N-dimethylamino)ethoxy)-7-oxo-7H-benzo(c)fluorene hydrochloride in rats after oral and…
3H-benfluorone administered orally to rats, persists for a long time in the stomach; it is absorbed only partly and eliminated… 
1984
1984
Chromatographic characterization of in vitro metabolites of 5-[2-(N,N-dimethylamino)ethoxy]-7-oxo-7H-benzo[c]fluorene.
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