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azalanstat

Known as: 1-(((2S,4S)-4-(((p-Aminophenyl)thio)methyl)-2-(p-chlorophenethyl)-1,3-dioxolan-2-yl)methyl)imidazole, Benzenamine, 4-(((2-(2-(4-chlorophenyl)ethyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methyl)thio)-, (2S-cis)- 
A synthetic imidazole that inhibits hepatic cholesterol biosynthesis by inhibiting the cytochrome P450 enzyme lanosterol 14alpha-demethylase. In an… 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

Aniline CompoundsSulfides

Narrower (1)

RS 21607

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
Structural Insights into Azole-based Inhibitors of Heme Oxygenase-1: Development of Selective Compounds for Therapeutic Applications.
The development of isozyme-selective heme oxygenase (HO) inhibitors promises powerful pharmacological tools to elucidate the… 
2009
2009
Synthesis and evaluation of imidazole-dioxolane compounds as selective heme oxygenase inhibitors: effect of substituents at the 4-position of the dioxolane ring.
2009
2009
Stage-specific Expression of Lanosterol 14-Demethylase in Mouse Oocytes in Relation to Fertilization and Embryo Development Competence
Follicular fluid meiosis-activating sterol (FF-MAS) has been suggested as a positive factor which could improve the oocyte… 
2009
2009
esign of a microbial sensor using conducting polymer of-( 2 , 5-di ( thiophen-2-yl )-1 H-pyrrole-1l ) benzenamine
A microbial biosensor based on Gluconobacter oxydans cells immobilized on the conducting polymer of 4-(2,5-di(thiophen-2-yl)-1H… 
2008
2008
Inhibition of heme oxygenase activity in newborn mice by azalanstat.
Inhibition of heme oxygenase (HO), the rate-limiting enzyme in heme catabolism, may be an ideal strategy for preventing neonatal… 
2007
2007
77 EFFICACY OF AZALANSTAT IN INHIBITING HEME OXYGENASE ACTIVITY IN NEWBORN MICE.
Heme oxygenase (HO) catalyzes the degradation of heme to produce bilirubin. Because excess bilirubin production can lead to the… 
Highly Cited
2006
Highly Cited
2006
Imidazole-dioxolane compounds as isozyme-selective heme oxygenase inhibitors.
Several imidazole-dioxolane compounds were synthesized and evaluated as novel inhibitors of heme oxygenase (HO). These compounds… 
2005
2005
The source of endogenous carbon monoxide formation in human placental chorionic villi.
Carbon monoxide (CO) is proposed to play a role in placental vascular control, as the placenta produces and responds to CO. The… 
1995
1995
Azalanstat (RS-21607), a lanosterol 14 alpha-demethylase inhibitor with cholesterol-lowering activity.
Agents that inhibit hepatic cholesterol biosynthesis reduce circulating cholesterol levels in experimental animals and humans… 
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