azalanstat

Known as: 1-(((2S,4S)-4-(((p-Aminophenyl)thio)methyl)-2-(p-chlorophenethyl)-1,3-dioxolan-2-yl)methyl)imidazole, Benzenamine, 4-(((2-(2-(4-chlorophenyl)ethyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methyl)thio)-, (2S-cis)- 
A synthetic imidazole that inhibits hepatic cholesterol biosynthesis by inhibiting the cytochrome P450 enzyme lanosterol 14alpha-demethylase. In an… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1995-2013
01219952013

Papers overview

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2013
2013
The development of heme oxygenase (HO) inhibitors, especially those that are isozyme-selective, promises powerful pharmacological… (More)
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2009
2009
Several imidazole-dioxolane compounds were synthesized and evaluated as novel inhibitors of heme oxygenase (HO). These compounds… (More)
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2008
2008
Inhibition of heme oxygenase (HO), the rate-limiting enzyme in heme catabolism, may be an ideal strategy for preventing neonatal… (More)
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2006
2006
Several imidazole-dioxolane compounds were synthesized and evaluated as novel inhibitors of heme oxygenase (HO). These compounds… (More)
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2006
2006
The expression of lanosterol 14alpha-demethylase (LDM) in the mouse ovary after gonadotrophin administration was examined and the… (More)
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2005
2005
Several analogues based on the lead structure of azalanstat were synthesized and evaluated as novel inhibitors of heme oxygenase… (More)
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2005
2005
Carbon monoxide (CO) is proposed to play a role in placental vascular control, as the placenta produces and responds to CO. The… (More)
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2001
2001
In vitro studies on mouse oocytes have shown that two closely related sterols, subsequently named meiosis-activating sterols (MAS… (More)
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1995
1995
Agents that inhibit hepatic cholesterol biosynthesis reduce circulating cholesterol levels in experimental animals and humans… (More)
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1995
1995
Lanosterol 14 alpha-demethylase (LDM) is a cytochrome P-450 enzyme in the biosynthetic pathway of cholesterol. As such, it… (More)
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