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atrophin-1

Known as: DRPLA protein, dentatorubral-pallidoluysian atrophy protein 
 
National Institutes of Health

Related topics

Related topics

3 relations
ATN1 gene

Narrower (1)

Drpla protein, rat

Broader (1)

Nerve Tissue Proteins

Papers overview

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Highly Cited
2006
Highly Cited
2006
Nuclear receptor TLX prevents retinal dystrophy and recruits the corepressor atrophin1.
During mammalian embryogenesis, precise coordination of progenitor cell proliferation and differentiation is essential for proper… Expand
Highly Cited
2006
Highly Cited
2006
Histone deacetylase-associating Atrophin proteins are nuclear receptor corepressors.
Drosophila Tailless (Tll) is an orphan nuclear receptor involved in embryonic segmentation and neurogenesis. Although Tll exerts… Expand
Highly Cited
2002
Highly Cited
2002
Drosophila Atrophin Homolog Functions as a Transcriptional Corepressor in Multiple Developmental Processes
Dentatorubral-pallidoluysian atrophy is a progressive neurodegenerative disease caused by the expansion of a polyglutamine… Expand
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Highly Cited
2002
Highly Cited
2002
Polyglutamine and transcription: gene expression changes shared by DRPLA and Huntington's disease mouse models reveal context-independent effects.
Recent evidence indicates that transcriptional abnormalities may play an important role in the pathophysiology of polyglutamine… Expand
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Highly Cited
2001
Highly Cited
2001
Widespread occurrence of intranuclear atrophin‐1 accumulation in the central nervous system neurons of patients with dentatorubral‐pallidoluysian atrophy
Dentatorubral‐pallidoluysian atrophy (DRPLA) is an autosomal dominant neurodegenerative disorder caused by a CAG repeat expansion… Expand
Highly Cited
2000
Highly Cited
2000
Atrophin-1, the Dentato-Rubral and Pallido-Luysian Atrophy Gene Product, Interacts with Eto/Mtg8 in the Nuclear Matrix and Represses Transcription
Dentato-rubral and pallido-luysian atrophy (DRPLA) is one of the family of neurodegenerative diseases caused by expansion of a… Expand
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Highly Cited
1999
Highly Cited
1999
Nuclear Accumulation of Truncated Atrophin-1 Fragments in a Transgenic Mouse Model of DRPLA
Dentatorubral and pallidoluysian atrophy (DRPLA) is a member of a family of progressive neurodegenerative diseases caused by… Expand
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Highly Cited
1999
Highly Cited
1999
Cleavage of Atrophin-1 at Caspase Site Aspartic Acid 109 Modulates Cytotoxicity*
Dentatorubropallidoluysian atrophy (DRPLA) is one of eight autosomal dominant neurodegenerative disorders characterized by an… Expand
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Highly Cited
1998
Highly Cited
1998
Caspase Cleavage of Gene Products Associated with Triplet Expansion Disorders Generates Truncated Fragments Containing the Polyglutamine Tract*
The neurodegenerative diseases Huntington disease, dentatorubropallidoluysian atrophy, spinocerebellar atrophy type 3, and spinal… Expand
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Highly Cited
1998
Highly Cited
1998
Atrophin-1, the DRPLA Gene Product, Interacts with Two Families of WW Domain-Containing Proteins
Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy (DRPLA… Expand
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