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arachidonic acid epoxygenase activity

Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to a cis-epoxyeicosatrienoic acid. [http://lipidlibrary.aocs.org… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1983-2006
02419832006

Papers overview

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2006
2006
Induction of renal cytochrome P450 arachidonic acid epoxygenase activity by dietary gamma-linolenic acid.
Dietary gamma-linolenic acid (GLA), a omega-6 polyunsaturated fatty acid found in borage oil (BOR), lowers systolic blood… (More)
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2006
2006
Induction of CYP1A and cyp2-mediated arachidonic acid epoxygenation and suppression of 20-hydroxyeicosatetraenoic acid by imidazole derivatives including the aromatase inhibitor vorozole.
Cytochrome P450 (P450) enzymes metabolize the membrane lipid arachidonic acid to stable biologically active epoxides… (More)
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Review
2006
Review
2006
Induction of Cyp1a and Cyp2-mediated Arachidonic Acid Epoxygenation and Suppression of 20-hydroxyeicosatetraenoic Acid by Imidazole Derivatives including the Aromatase
Cytochrome P450 (P450) enzymes metabolize the membrane lipid arachidonic acid to stable biologically active epoxides… (More)
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2006
2006
Having a heart attack? Avoid the "HETE"!
ISCHEMIA-REPERFUSION (I/R) injury plays a major role in the pathogenesis of cardiac complications, such as myocardial infarction… (More)
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Highly Cited
2001
Highly Cited
2001
Overexpression of cytochrome P450 CYP2J2 protects against hypoxia-reoxygenation injury in cultured bovine aortic endothelial cells.
CYP2J2 is abundant in human heart and its arachidonic acid metabolites, the epoxyeicosatrienoic acids (EETs), have potent… (More)
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2000
2000
Adenoviral vector-mediated transfer of human heme oxygenase in rats decreases renal heme-dependent arachidonic acid epoxygenase activity.
Intravenous administration of an adenovirus human heme oxygenase (HO)-1 gene construct to rats resulted in functional expression… (More)
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2000
2000
TCDD induces CYP1A4 and CYP1A5 in chick liver and kidney and only CYP1A4, an enzyme lacking arachidonic acid epoxygenase activity, in myocardium and vascular endothelium.
The toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and other Ah receptor ligands, species differences in sensitivity and… (More)
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Highly Cited
1995
Highly Cited
1995
Arachidonic acid metabolism by human cytochrome P450s 2C8, 2C9, 2E1, and 1A2: regioselective oxygenation and evidence for a role for CYP2C enzymes in arachidonic acid epoxygenation in human liver…
The membrane-bound endogenous fatty acid arachidonic acid can be released from membranes by phospholipases and then metabolized… (More)
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1984
1984
Epoxygenation of arachidonic acid by rat anterior pituitary microsomal fractions.
Microsomal fractions isolated from rat anterior pituitary glands catalyze the oxygenation of arachidonic acid. By a combination… (More)
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1983
1983
Epoxyeicosatrienoic acids stimulate glucagon and insulin release from isolated rat pancreatic islets.
Metapyrone and eicosatetraynoic acid but not indomethacin are effective inhibitors of the secretory response of isolated rat… (More)
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