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arachidonic acid epoxygenase activity

Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to a cis-epoxyeicosatrienoic acid. [http://lipidlibrary.aocs.org… Expand
National Institutes of Health

Papers overview

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2019
2019
Abstract LB-023: CYP monooxygenases regulate nuclear localization of ERá and mTORC1 component RagC in ER+HER2- breast cancer cells
Introduction: Cancer cell-intrinsic CYP monooxygenases promote tumor progression. In ER+ breast cancer cells, CYP3A4 is required… Expand
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2006
2006
Induction of renal cytochrome P450 arachidonic acid epoxygenase activity by dietary gamma-linolenic acid.
Dietary gamma-linolenic acid (GLA), a omega-6 polyunsaturated fatty acid found in borage oil (BOR), lowers systolic blood… Expand
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2006
2006
Induction of CYP1A and cyp2-mediated arachidonic acid epoxygenation and suppression of 20-hydroxyeicosatetraenoic acid by imidazole derivatives including the aromatase inhibitor vorozole.
Cytochrome P450 (P450) enzymes metabolize the membrane lipid arachidonic acid to stable biologically active epoxides… Expand
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2006
2006
Having a heart attack? Avoid the "HETE"!
ischemia-reperfusion (I/R) injury plays a major role in the pathogenesis of cardiac complications, such as myocardial infarction… Expand
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Highly Cited
2001
Highly Cited
2001
Overexpression of cytochrome P450 CYP2J2 protects against hypoxia-reoxygenation injury in cultured bovine aortic endothelial cells.
CYP2J2 is abundant in human heart and its arachidonic acid metabolites, the epoxyeicosatrienoic acids (EETs), have potent… Expand
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2001
2001
Overexpression of Cytochrome P 450 CYP 2 J 2 Protects against Hypoxia-Reoxygenation Injury in Cultured Bovine Aortic Endothelial Cells
CYP2J2 is abundant in human heart and its arachidonic acid metabolites, the epoxyeicosatrienoic acids (EETs), have potent… Expand
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2000
2000
Adenoviral vector-mediated transfer of human heme oxygenase in rats decreases renal heme-dependent arachidonic acid epoxygenase activity.
Intravenous administration of an adenovirus human heme oxygenase (HO)-1 gene construct to rats resulted in functional expression… Expand
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1983
1983
Epoxyeicosatrienoic acids stimulate glucagon and insulin release from isolated rat pancreatic islets.
Metapyrone and eicosatetraynoic acid but not indomethacin are effective inhibitors of the secretory response of isolated rat… Expand
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