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apstatin

Known as: N-((2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl)-L-prolyl-L-prolyl-L-alaninamide 
National Institutes of Health

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Broader (1)

Peptides

Papers overview

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2004
2004
Structure of Escherichia coli aminopeptidase P in complex with the inhibitor apstatin.
Aminopeptidase P (APPro) is a metalloprotease whose active site includes a dinuclear manganese(II) cluster. The enzyme cleaves… 
2004
2004
Involvement of nitric oxide and prostaglandin pathways in the cardioprotective actions of bradykinin in rats with experimental myocardial infarction.
Highly Cited
2002
Highly Cited
2002
Cloning and Characterization of a Leucyl Aminopeptidase from Three Pathogenic Leishmania Species*
Aminopeptidases are emerging as exciting novel drug targets and vaccine candidates in parasitic infections. In this study, we… 
2001
2001
Effects of the Aminopeptidase P Inhibitor Apstatin on Bradykinin-Induced Inositol 1,4,5-Triphosphate in Neonatal Rat Cardiomyocytes
We investigated the effect of apstatin (an aminopeptidase P inhibitor) on bradykinin-induced inositol 1,4,5-triphosphate (IP3… 
2000
2000
Vascular catabolism of bradykinin in the isolated perfused rat kidney.
1999
1999
Apstatin analogue inhibitors of aminopeptidase P, a bradykinin-degrading enzyme.
Membrane-bound aminopeptidase P (AP-P) participates in the degradation of bradykinin in several vascular beds. We have developed… 
Highly Cited
1997
Highly Cited
1997
Intravascular and interstitial degradation of bradykinin in isolated perfused rat heart
1 Bradykinin (BK) has been shown to exert cardioprotective effects which are potentiated by inhibitors of angiotensin I… 
1996
1996
Chemical modification of porcine kidney aminopeptidase P indicates the involvement of two critical histidine residues
1996
1996
Potentiation of the pro-inflammatory effects of bradykinin by inhibition of angiotensin-converting enzyme and aminopeptidase P in rat paws
The influence of some peptidase inhibitors on oedema and plasma extravasation induced by bradykinin and carrageenan in rat paw… 
Highly Cited
1995
Highly Cited
1995
Purification and properties of membrane-bound aminopeptidase P from rat lung.
The membrane-bound form of aminopeptidase P (aminoacylprolyl-peptide hydrolase) (EC 3.4.11.9) was purified 670-fold to apparent… 
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