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aplyronine A

National Institutes of Health

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Macrolides

Papers overview

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2019
2019
Synthesis and Biological Activities of Aplyronine A Analogues toward the Development of Antitumor Protein–Protein Interaction Inducers between Actin and Tubulin: Conjugation of the C1–C9 Macrolactone…
Aplyronine A (ApA) is an antitumor marine macrolide that induces an protein–protein interaction (PPI) between actin and tubulin… 
2016
2016
Second-generation total synthesis of aplyronine A featuring Ni/Cr-mediated coupling reactions.
Second-generation total synthesis of aplyronine A, a potent antitumor marine macrolide, was achieved using Ni/Cr-mediated… 
2016
2016
Study on the Mode of Action of Marine Natural Product Aplyronine A by Using Novel Chemical Probes
2013
2013
The Mode of Action of an Antitumor Macrolide Aplyronine A, Which Induces a New Protein-Protein Interaction
Aplyronine A (ApA) is a marine natural product that shows potent antitumor activity. The primary target of ApA was found to be… 
2013
2013
Osmium catalyzed dihydroxylation and oxidative cleavage of vinyl sulfone and elucidation of the vinylsulfone polypropionate methodology for the synthesis of the C32 des-methyl C28-C34 actin binding…
Cyclic asymmetric vinylsulfones and vinyphosphonates have been used towards the synthesis of aplyronine A and discodermolide… 
2011
2011
Toward the second generation synthesis of aplyronine A: stereocontrolled assembly of the C1-C19 segment by using an asymmetric Nozaki-Hiyama-Kishi coupling.
An efficient synthesis of the C1-C19 segment of aplyronine A is described. Stereoselective construction of the C14-C15 (E… 
2010
2010
Molecular docking and QSAR of aplyronine A and analogues: potent inhibitors of actin
Actin-binding natural products have been identified as a potential basis for the design of cancer therapeutic agents. We report… 
Highly Cited
1996
Highly Cited
1996
Novel actin depolymerizing macrolide aplyronine A.
Aplyronine A is a macrolide isolated from Aplysia kurodai. By monitoring fluorescent intensity of pyrenyl-actin, it was found… 
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