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ansamycin biosynthetic process

Known as: ansamycin biosynthesis, ansamycin formation, ansamycin synthesis 
The chemical reactions and pathways leading to the formation of ansamycins, any of a group of complex macrolactam compounds characterized by a cyclic… 
National Institutes of Health

Papers overview

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2013
2013
Harnessing the Potential of Halogenated Natural Product Biosynthesis by Mangrove-Derived Actinomycetes
Mangrove-derived actinomycetes are promising sources of bioactive natural products. In this study, using homologous screening of… 
2010
2010
Cyclization of Synthetic seco‐Proansamitocins to Ansamitocin Macrolactams by Actinosynnema pretiosum as Biocatalyst
The plant-derived maytansinoids 4[1] and their microbial counterparts, the ansamitocins P-2 to P-4 5-7 (Figure 1) [2] exert… 
2006
2006
Production of Ansamycin Polyketide Precursors in Escherichia coli
For the heterologous production of ansamycin polyketides such as rifamycin and geldanamycin in Escherichia coli, a number of… 
2005
2005
Rifampin-Resistant RNA Polymerase Mutants of Chlamydia trachomatis Remain Susceptible to the Ansamycin Rifalazil
ABSTRACT Stable, homotypic mutants of Chlamydia trachomatis for which MICs of rifampin and rifalazil are elevated were isolated… 
2005
2005
Potent Activity of a Novel Dimeric Heat Shock Protein 90 Inhibitor against Head and Neck Squamous Cell Carcinoma In vitro and In vivo
Heat shock protein 90 (Hsp90) is a molecular chaperone that promotes the conformational maturation of numerous client proteins… 
Highly Cited
1998
Highly Cited
1998
Genetic and Biochemical Analysis of p23 and Ansamycin Antibiotics in the Function of Hsp90-Dependent Signaling Proteins
ABSTRACT The ubiquitous molecular chaperone Hsp90 acts in concert with a cohort of associated proteins to facilitate the… 
Highly Cited
1997
Highly Cited
1997
Effects of the tyrosine‐kinase inhibitor geldanamycin on ligand‐induced HER‐2/NEU activation, receptor expression and proliferation of HER‐2‐positive malignant cell lines
Geldanamycin belongs to the family of benzoquinoid ansamycin tyrosine‐kinase inhibitors. We have examined its effects on Her‐2… 
Highly Cited
1994
Highly Cited
1994
Depletion of the erbB-2 gene product p185 by benzoquinoid ansamycins.
Herbimycin A, a benzoquinoid ansamycin, is widely used as an inhibitor of tyrosine kinases. We have examined the effects of… 
1994
1994
In vivo antitumor activity of herbimycin A, a tyrosine kinase inhibitor, targeted against BCR/ABL oncoprotein in mice bearing BCR/ABL-transfected cells.
1984
1984
Isolierung und Strukturaufklärung neuer antifungischer Makrolid- und Ansamycin-Antibiotika
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