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ansamycin biosynthetic process

Known as: ansamycin biosynthesis, ansamycin formation, ansamycin synthesis 
The chemical reactions and pathways leading to the formation of ansamycins, any of a group of complex macrolactam compounds characterized by a cyclic… Expand
National Institutes of Health

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2019
2019
Targeted Discovery of Pentaketide Ansamycin Aminoansamycins A-G.
Ansamycins are a class of macrolactams with diverse bioactivities, characterized by the unique 3-amino-5-hydroxybenzoic acid… Expand
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Highly Cited
2017
Highly Cited
2017
Compositionally and functionally distinct sinus microbiota in chronic rhinosinusitis patients have immunological and clinically divergent consequences
BackgroundChronic rhinosinusitis (CRS) is a heterogeneous disease characterized by persistent sinonasal inflammation and sinus… Expand
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2010
2010
Cyclization of synthetic seco-proansamitocins to ansamitocin macrolactams by Actinosynnema pretiosum as biocatalyst.
The plant-derived maytansinoids 4[1] and their microbial counterparts, the ansamitocins P-2 to P-4 5-7 (Figure 1) [2] exert… Expand
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2005
2005
Rifampin-resistant RNA polymerase mutants of Chlamydia trachomatis remain susceptible to the ansamycin rifalazil.
Stable, homotypic mutants of Chlamydia trachomatis for which MICs of rifampin and rifalazil are elevated were isolated by serial… Expand
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2005
2005
Potent Activity of a Novel Dimeric Heat Shock Protein 90 Inhibitor against Head and Neck Squamous Cell Carcinoma In vitro and In vivo
Heat shock protein 90 (Hsp90) is a molecular chaperone that promotes the conformational maturation of numerous client proteins… Expand
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1998
1998
Genetic and biochemical analysis of p23 and ansamycin antibiotics in the function of Hsp90-dependent signaling proteins.
  • Sean P. Bohen
  • Molecular and cellular biology
  • 1998
    • Corpus ID: 28878092
The ubiquitous molecular chaperone Hsp90 acts in concert with a cohort of associated proteins to facilitate the functional… Expand
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1997
1997
Effects of the tyrosine-kinase inhibitor geldanamycin on ligand-induced Her-2/neu activation, receptor expression and proliferation of Her-2-positive malignant cell lines.
Geldanamycin belongs to the family of benzoquinoid ansamycin tyrosine-kinase inhibitors. We have examined its effects on Her-2… Expand
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Highly Cited
1994
Highly Cited
1994
Depletion of the erbB-2 gene product p185 by benzoquinoid ansamycins.
Herbimycin A, a benzoquinoid ansamycin, is widely used as an inhibitor of tyrosine kinases. We have examined the effects of… Expand
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1994
1994
In vivo antitumor activity of herbimycin A, a tyrosine kinase inhibitor, targeted against BCR/ABL oncoprotein in mice bearing BCR/ABL-transfected cells.
Herbimycin A, a benzoquinoid ansamycin antibiotic, has been shown to reverse the oncogenic phenotype of p60v-src transformed… Expand
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1984
1984
Isolierung und Strukturaufklärung neuer antifungischer Makrolid- und Ansamycin-Antibiotika
 
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