amphethinile

Phase I studies requiring multiple dose escalation steps have led to the development of pharmacokinetically guided dose… Expand

The novel agents amphethinile and combretastatin A4 are shown to be very similar to colchicine in their interactions with… Expand

The novel agent amphethinile is shown to inhibit tubulin assembly in vitro. This agent is capable of displacing colchicine but… Expand

 

Amphethinile is a new spindle poison with a novel structure that has shown activity in the L1210, ADJ/PC6 and Walker carcinoma… Expand

A new antitumour agent is described, which has been shown to induce a G2/M block in murine leukaemia cells in vitro. In addition… Expand