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amphethinile

Known as: 2-amino-3-cyano-5-(phenylthio)indole 
National Institutes of Health

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Papers overview

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Review
1992
Review
1992
The impact of pharmacokinetically guided dose escalation strategies in phase I clinical trials: critical evaluation and recommendations for future studies.
Phase I studies requiring multiple dose escalation steps have led to the development of pharmacokinetically guided dose… 
Highly Cited
1989
Highly Cited
1989
Structural and biochemical comparison of the anti-mitotic agents colchicine, combretastatin A4 and amphethinile.
The novel agents amphethinile and combretastatin A4 are shown to be very similar to colchicine in their interactions with… 
1989
1989
Interaction of the novel agent amphethinile with tubulin.
The novel agent amphethinile is shown to inhibit tubulin assembly in vitro. This agent is capable of displacing colchicine but… 
1988
1988
A phase I and pharmacokinetic study of amphethinile.
Amphethinile is a new spindle poison with a novel structure that has shown activity in the L1210, ADJ/PC6 and Walker carcinoma… 
1988
1988
Pre-clinical studies of a novel anti-mitotic agent, amphethinile.
A new antitumour agent is described, which has been shown to induce a G2/M block in murine leukaemia cells in vitro. In addition… 
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