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amphethinile
Known as:
2-amino-3-cyano-5-(phenylthio)indole
National Institutes of Health
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Review
1992
Review
1992
The impact of pharmacokinetically guided dose escalation strategies in phase I clinical trials: critical evaluation and recommendations for future studies.
M. Graham
,
P. Workman
Annals of oncology : official journal of the…
1992
Corpus ID: 842703
Phase I studies requiring multiple dose escalation steps have led to the development of pharmacokinetically guided dose…
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Highly Cited
1989
Highly Cited
1989
Structural and biochemical comparison of the anti-mitotic agents colchicine, combretastatin A4 and amphethinile.
A. McGown
,
B. Fox
Anti-cancer drug design
1989
Corpus ID: 7154205
The novel agents amphethinile and combretastatin A4 are shown to be very similar to colchicine in their interactions with…
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1989
1989
Interaction of the novel agent amphethinile with tubulin.
A. Mcgown
,
B. Fox
British Journal of Cancer
1989
Corpus ID: 5580145
The novel agent amphethinile is shown to inhibit tubulin assembly in vitro. This agent is capable of displacing colchicine but…
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1988
1988
A phase I and pharmacokinetic study of amphethinile.
D. Smith
,
C. Ewen
,
+5 authors
D. Crowther
British Journal of Cancer
1988
Corpus ID: 12668999
Amphethinile is a new spindle poison with a novel structure that has shown activity in the L1210, ADJ/PC6 and Walker carcinoma…
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1988
1988
Pre-clinical studies of a novel anti-mitotic agent, amphethinile.
A. McGown
,
C. Ewen
,
D. Smith
,
B. Fox
British Journal of Cancer
1988
Corpus ID: 12918267
A new antitumour agent is described, which has been shown to induce a G2/M block in murine leukaemia cells in vitro. In addition…
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