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aliskiren

Known as: (2S,4S,5S,7S)-5-Amino-N-(2-carbamoyl-2-methylpropyl)-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonamide, aliskiren [Chemical/Ingredient] 
An orally active nonpeptide renin inhibitor with antihypertensive activity. Aliskiren selectively binds to the S3 sub-pocket of renin, an enzyme in… Expand
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
IMPORTANCE Hospitalizations for heart failure (HHF) represent a major health burden, with high rates of early postdischarge… Expand
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Highly Cited
2012
Highly Cited
2012
BACKGROUND This study was undertaken to determine whether use of the direct renin inhibitor aliskiren would reduce cardiovascular… Expand
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Review
2012
Review
2012
Blockade of the renin–angiotensin system (RAS) is a core therapeutic strategy in systolic heart failure.1 The value of… Expand
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Highly Cited
2008
Highly Cited
2008
BACKGROUND Diabetic nephropathy is the leading cause of end-stage renal disease in developed countries. We evaluated the… Expand
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Highly Cited
2008
Highly Cited
2008
Background—Loss of negative feedback inhibition of renin release during chronic treatment with an angiotensin-converting enzyme… Expand
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Highly Cited
2008
Highly Cited
2008
The aim of this study was to explore the effects of the renin inhibitor aliskiren in streptozotocin-diabetic TG(mRen-2)27 rats… Expand
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Highly Cited
2005
Highly Cited
2005
Background—Stopping the detrimental effects of the renin-angiotensin system at the most upstream point of the cascade offers… Expand
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Highly Cited
2003
Highly Cited
2003
Hypertension is a major risk factor for cardiovascular diseases such as stroke, myocardial infarction, and heart failure, the… Expand
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Highly Cited
2003
Highly Cited
2003
Abstract—Inhibition of the first and rate-limiting step of the renin-angiotensin system has long been an elusive therapeutic goal… Expand
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Highly Cited
2002
Highly Cited
2002
Renin is the main determinant of angiotensin (Ang) II levels. It, therefore, always appeared desirable to reduce Ang II levels by… Expand
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