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aliskiren

Known as: (2S,4S,5S,7S)-5-Amino-N-(2-carbamoyl-2-methylpropyl)-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonamide, aliskiren [Chemical/Ingredient] 
An orally active nonpeptide renin inhibitor with antihypertensive activity. Aliskiren selectively binds to the S3 sub-pocket of renin, an enzyme in… 
National Institutes of Health

Related topics

Related topics

14 relations

Broader (2)

AmidesFumarates

Narrower (5)

CGP 060536BSPP100TekamloTekturna
CGP 60536Renin Inhibitors [MoA]aliskiren / Amlodipinealiskiren / Hydrochlorothiazide

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2016
Review
2016
Mechanistic insight of diabetic nephropathy and its pharmacotherapeutic targets: An update.
Highly Cited
2014
Highly Cited
2014
Effects of renin-angiotensin-aldosterone system inhibitors and beta-blockers on markers of arterial stiffness.
Review
2012
Review
2012
Targeting NADPH oxidases in vascular pharmacology.
Highly Cited
2009
Highly Cited
2009
Aliskiren Trial in Type 2 Diabetes Using Cardio-Renal Endpoints (ALTITUDE): rationale and study design.
BACKGROUND Patients with type 2 diabetes are at increased risk of macro- and microvascular disease, and the presence of… 
Highly Cited
2008
Highly Cited
2008
Renal and Hormonal Responses to Direct Renin Inhibition With Aliskiren in Healthy Humans
Background— Pharmacological interruption of the renin-angiotensin system focuses on optimization of blockade. As a measure of… 
Highly Cited
2008
Highly Cited
2008
Prorenin engages the (pro)renin receptor like renin and both ligand activities are unopposed by aliskiren
Objectives Inhibition of (pro)renin receptor activation was demonstrated to inhibit or even abolish the development of end-organ… 
Highly Cited
2007
Highly Cited
2007
Aliskiren Reduces Blood Pressure and Suppresses Plasma Renin Activity in Combination With a Thiazide Diuretic, an Angiotensin-Converting Enzyme Inhibitor, or an Angiotensin Receptor Blocker
Thiazide diuretics, angiotensin-converting enzyme inhibitors, and angiotensin receptor blockers all cause reactive rises in… 
Review
2006
Review
2006
Renin inhibition with aliskiren: where are we now, and where are we going?
With the development of aliskiren, blockade of the renin-angiotensin-aldosterone system (RAAS) at the level of the interaction of… 
Highly Cited
2005
Highly Cited
2005
Aliskiren, a Human Renin Inhibitor, Ameliorates Cardiac and Renal Damage in Double-Transgenic Rats
We tested the hypothesis that the renin inhibitor aliskiren ameliorates organ damage in rats transgenic for human renin and… 
Highly Cited
2005
Highly Cited
2005
Aliskiren, a novel, orally effective renin inhibitor, lowers blood pressure in marmosets and spontaneously hypertensive rats
Objectives Aliskiren is a new renin inhibitor of a novel structural class that has recently been shown to be efficacious in… 
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