aliskiren

Known as: (2S,4S,5S,7S)-5-Amino-N-(2-carbamoyl-2-methylpropyl)-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonamide, aliskiren [Chemical/Ingredient] 
An orally active nonpeptide renin inhibitor with antihypertensive activity. Aliskiren selectively binds to the S3 sub-pocket of renin, an enzyme in… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2002-2018
05010020022018

Papers overview

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Highly Cited
2012
Highly Cited
2012
BACKGROUND This study was undertaken to determine whether use of the direct renin inhibitor aliskiren would reduce cardiovascular… (More)
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Highly Cited
2009
Highly Cited
2009
BACKGROUND Left ventricular (LV) hypertrophy, a marker of cardiac end-organ damage, is associated with an increased risk of… (More)
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Highly Cited
2008
Highly Cited
2008
BACKGROUND Diabetic nephropathy is the leading cause of end-stage renal disease in developed countries. We evaluated the… (More)
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Highly Cited
2008
Highly Cited
2008
The recently cloned (pro)renin receptor [(P)RR] mediates renin-stimulated cellular effects by activating mitogen-activated… (More)
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Highly Cited
2008
Highly Cited
2008
BACKGROUND Loss of negative feedback inhibition of renin release during chronic treatment with an angiotensin-converting enzyme… (More)
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Highly Cited
2007
Highly Cited
2007
BACKGROUND The aim of this study was to assess dual renin system intervention with the maximum recommended doses of aliskiren and… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Stopping the detrimental effects of the renin-angiotensin system at the most upstream point of the cascade offers… (More)
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Highly Cited
2003
Highly Cited
2003
Hypertension is a major risk factor for cardiovascular diseases such as stroke, myocardial infarction, and heart failure, the… (More)
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Highly Cited
2003
Highly Cited
2003
Inhibition of the first and rate-limiting step of the renin-angiotensin system has long been an elusive therapeutic goal… (More)
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Highly Cited
2002
Highly Cited
2002
Renin is the main determinant of angiotensin (Ang) II levels. It, therefore, always appeared desirable to reduce Ang II levels by… (More)
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