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aliskiren

Known as: (2S,4S,5S,7S)-5-Amino-N-(2-carbamoyl-2-methylpropyl)-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonamide, aliskiren [Chemical/Ingredient] 
An orally active nonpeptide renin inhibitor with antihypertensive activity. Aliskiren selectively binds to the S3 sub-pocket of renin, an enzyme in… 
National Institutes of Health

Related topics

Related topics

14 relations

Broader (2)

AmidesFumarates

Narrower (5)

CGP 060536BSPP100TekamloTekturna
CGP 60536Renin Inhibitors [MoA]aliskiren / Amlodipinealiskiren / Hydrochlorothiazide

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Aliskiren alleviates doxorubicin-induced nephrotoxicity by inhibiting oxidative stress and podocyte injury
Introduction: Doxorubicin (DXR) is one of the most effective and widely used anthracycline antibiotics. However, its clinical… 
Highly Cited
2012
Highly Cited
2012
In vitro controlled release of antihypertensive drugs intercalated into unmodified SBA-15 and MgO modified SBA-15 matrices.
2010
2010
Aliskiren enhances protective effects of valsartan against type 2 diabetic nephropathy in mice
Objectives Addition of aliskiren, a direct renin inhibitor, to losartan provides additive reduction of urinary albumin excretion… 
2010
2010
Optimal antiproteinuric dose of aliskiren in type 2 diabetes mellitus: a randomised crossover trial
AimThe optimal antiproteinuric dose of aliskiren is unknown. This study compared the effect of placebo and increasing doses of… 
Highly Cited
2009
Highly Cited
2009
Aliskiren prevents cardiovascular complications and pancreatic injury in a mouse model of obesity and type 2 diabetes
Aims/hypothesisThe effect of renin inhibition on type 2 diabetes is still unclear. The present study was undertaken to examine… 
2008
2008
Heparin comes clean.
Hypotensive episodes in patients receiving heparin by means of injection, some of which cause death, are voluntarily reported to… 
Review
2008
Review
2008
Aliskiren—mode of action and preclinical data
Hypertension is one of the major health care problems worldwide since it markedly increases the risk for development of heart… 
Review
2008
Review
2008
Pharmacokinetics and pharmacodynamics of aliskiren, an oral direct renin inhibitor.
Intensive efforts have been spent to discover therapeutic, non-peptide and orally effective hypertensive drugs. One drug that… 
Highly Cited
2007
Highly Cited
2007
Antihypertensive Efficacy of the Oral Direct Renin Inhibitor Aliskiren as Add‐On Therapy in Patients Not Responding to Amlodipine Monotherapy
This study investigated the addition of the direct renin inhibitor aliskiren to amlodipine in patients with mild to moderate… 
Highly Cited
2007
Highly Cited
2007
Safety and efficacy of the oral direct renin inhibitor aliskiren in elderly patients with hypertension
Objectives. To evaluate the efficacy, safety and tolerability of aliskiren in elderly patients (⩾65 years old) with essential… 
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