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aklaviketone

National Institutes of Health

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Naphthacenes

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2001
2001
Isolation and characterization of stable mutants ofStreptomyces peucetius defective in daunorubicin biosynthesis
Daunorubicin and its derivative doxorubicin are antitumour anthracycline antibiotics produced byStreptomyces peucetius. In this… 
1999
1999
DnrD cyclase involved in the biosynthesis of doxorubicin: purification and characterization of the recombinant enzyme.
Mutations in the Streptomyces peucetius dnrD gene block the ring cyclization leading from aklanonic acid methyl ester (AAME) to… 
1996
1996
Cloning, sequencing, and analysis of aklaviketone reductase from Streptomyces sp. strain C5
DNA sequence analysis of a region of the Streptomyces sp. strain C5 daunomycin biosynthesis gene cluster, located just upstream… 
1993
1993
Tetracenomycin F2 cyclase: intramolecular aldol condensation in the biosynthesis of tetracenomycin C in Streptomyces glaucescens.
Tetracenomycin (Tcm) F2 cyclase, which catalyzes the cyclization of the anthrone Tcm F2 to the naphthacenone Tcm F1 in the… 
1988
1988
Biosynthesis of anthracyclinones: isolation of a new early cyclization product aklaviketone.
Five metabolites were isolated from fermentations of a mutant strain S 383 of Streptomyces galilaeus. Components S 383-O and S… 
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