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aklaviketone

 
National Institutes of Health

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Naphthacenes

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2008
2008
Isolation and characterization of stable mutants ofStreptomyces peucetius defective in daunorubicin biosynthesis
Daunorubicin and its derivative doxorubicin are antitumour anthracycline antibiotics produced byStreptomyces peucetius. In this… Expand
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1999
1999
DnrD cyclase involved in the biosynthesis of doxorubicin: purification and characterization of the recombinant enzyme.
Mutations in the Streptomyces peucetius dnrD gene block the ring cyclization leading from aklanonic acid methyl ester (AAME) to… Expand
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1996
1996
Cloning, sequencing, and analysis of aklaviketone reductase from Streptomyces sp. strain C5.
DNA sequence analysis of a region of the Streptomyces sp. strain C5 daunomycin biosynthesis gene cluster, located just upstream… Expand
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1993
1993
Tetracenomycin F2 cyclase: intramolecular aldol condensation in the biosynthesis of tetracenomycin C in Streptomyces glaucescens.
Tetracenomycin (Tcm) F2 cyclase, which catalyzes the cyclization of the anthrone Tcm F2 to the naphthacenone Tcm F1 in the… Expand
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1988
1988
Biosynthesis of anthracyclinones: isolation of a new early cyclization product aklaviketone.
Five metabolites were isolated from fermentations of a mutant strain S 383 of Streptomyces galilaeus. Components S 383-O and S… Expand
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