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Ischemic bowel remains a critical problem, resulting in up to 80% mortality. Acute lung injury, a common complication… Expand Objective:Irreversible hypovolemia remains a major clinical problem. Preliminary studies indicate that administration of… Expand Objective:To determine whether vascular endothelial cell apoptosis occurs in the late stage of sepsis and, if so, whether… Expand Recent studies have demonstrated that administration of adrenomedullin (AM) and AM binding protein-1 (AMBP-1) maintains… Expand Adrenomedullin (AM) is a recently discovered, potent vasodilatory peptide with activities including maintenance of cardiovascular… Expand Adrenomedullin is a multifunctional amidated peptide that has been found in most nuclei of the CNS, where it plays a… Expand The calcitonin receptor‐like receptor (CRLR) and specific receptor activity modifying proteins (RAMPs) together form receptors… Expand Adrenomedullin might be a much more important player in vascular function than previously thought. The Adm knockout models… Expand Putative receptors for CGRP and adrenomedullin have been investigated in the rat. Calcitonin Receptor‐Like Receptor (CRLR), in… Expand We have previously demonstrated specific binding sites for adrenomedullin, a novel member of the calcitonin family of peptides… Expand