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adibendan
Known as:
7,7-dimethyl-2-(4-pyridyl)-6,7-dihydro-3H,5H pyrrolo (2,3-f)benz-imidazol-6-one
, Pyrrolo(2,3-f)benzimidazol-6(1H)-one, 5,7-dihydro-7,7-dimethyl-2-(4-pyridinyl)-
National Institutes of Health
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Related topics
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1 relation
Broader (1)
Benzimidazoles
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
1992
1992
Inhibition of human cardiac cyclic AMP-phosphodiesterases by R 80122, a new selective cyclic AMP-phosphodiesterase III inhibitor: a comparison with other cardiotonic compounds.
D. de Cheffoy de Courcelles
,
K. De Loore
,
E. Freyne
,
P. Janssen
Journal of Pharmacology and Experimental…
1992
Corpus ID: 24641381
Four cyclic AMP (cAMP)-phosphodiesterases (PDE) belonging to families I, II, III and IV were identified in homogenates from human…
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1992
1992
Phosphodiesterase inhibition and positive inotropy in failing human myocardium.
W. Schmitz
,
T. Eschenhagen
,
U. Mende
,
F. Müller
,
J. Neumann
,
H. Scholz
Basic Research in Cardiology
1992
Corpus ID: 31644540
Positive inotropic effects of phosphodiesterase inhibitors like 3-isobutyl-1-methylxanthine (IBMX), pimobendan, adibendan…
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1992
1992
In Vitro Pharmacology of R 80122, a Novel Phosphodiesterase Inhibitor
D. Wilhelm
,
B. Wilffert
,
+4 authors
T. Peters
Journal of Cardiovascular Pharmacology
1992
Corpus ID: 2829846
Summary: The cardiac in vitro effects of R 80122, a novel phosphodiesterase (PDE) inhibitor, were investigated and compared with…
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1991
1991
Mechanism underlying the reduced positive inotropic effects of the phosphodiesterase III inhibitors pimobendan, adibendan and saterinone in failing as compared to nonfailing human cardiac muscle…
H. Leyen
,
U. Mende
,
+10 authors
A. Haverich
Naunyn-Schmiedeberg's Archives of Pharmacology
1991
Corpus ID: 12977158
SummaryThe present study was performed to compare the effects of the new positive inotropic phosphodiesterase III inhibitors…
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1989
1989
Nonsteroidal cardiotonics. 2. The inotropic activity of linear, tricyclic 5-6-5 fused heterocycles.
W. von der Saal
,
Jens-Peter Hoelck
,
Wolfgang Kampe
,
A. Mertens
,
Bernd Mueller-Beckmann
Journal of Medicinal Chemistry
1989
Corpus ID: 22795902
We previously reported the structure-activity relationships (SAR) of adibendan (1), a potent and long-acting cardiotonic. This…
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1989
1989
Calcium-sensitivity modulation of cardiac myofibrillar proteins.
J. Rüegg
,
I. Morano
Journal of Cardiovascular Pharmacology
1989
Corpus ID: 19866600
Myocardial contractile force may be altered not only by changing intracellular free Ca2+ but also by increasing or decreasing the…
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1989
1989
Comparison of the effects of MCI-154, a new cardiotonic agent, and some Ca2+-sensitizing agents on the response of the contractile system to Ca2+ in skinned cardiac muscle.
Y. Kitada
,
M. Morita
,
A. Narimatsu
Japanese Journal of Pharmacology
1989
Corpus ID: 8915881
Several cardiotonic agents (MCI-154, sulmazole, pimobendan and adibendan) were examined for their ability to influence Ca2…
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1989
1989
Acute hemodynamic effects of adibendan, a new phosphodiesterase inhibitor, for severe congestive heart failure.
W. Voelker
,
M. Mauser
,
M. Preisack
,
K. Karsch
American Journal of Cardiology
1989
Corpus ID: 2030437
1988
1988
In Vitro Investigations on a New Positive Inotropic and Vasodilating Agent (BM 14.478) That Increases Myocardial Cyclic AMP Content and Myofibrillar Calcium Sensitivity
B. Müller-Beckmann
,
P. Freund
,
P. Honerjäger
,
L. Kling
,
J. Rüegg
Journal of Cardiovascular Pharmacology
1988
Corpus ID: 41510444
Summary: BM 14.478 (7,7-dimethyl-2-(4-pyridyl)-6,7-dihydro-3H,5H pyrrolo[2,3-f]benz-imidazol-6-one) was investigated in several…
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1988
1988
Mechanism of action and cardiotonic activity of a new phosphodiesterase inhibitor, the benzimidazole derivative adibendan (BM 14.478), in guinea-pig hearts
T. Bethke
,
D. Brunkhorst
,
H. Leyen
,
W. Meyer
,
Rüdiger Nigbur
,
H. Scholz
Naunyn-Schmiedeberg's Archives of Pharmacology
1988
Corpus ID: 33835115
Summary1.The effects of adibendan (BM 14.478; 7,7-dimethyl-2-(4-pyridyl)-6,7-dihydro-3H,5H-pyrrolo[2,3-fl benzimidazole-6-one) on…
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