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activator of DNA replication

 
National Institutes of Health

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Serine Endopeptidases

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1993
1993
Cyclosporine and rapamycin affect protein kinase C induction of the intracellular activation signal, activator of DNA replication.
Immunosuppressive agents may initiate their pharmacologic action by disrupting phosphorylation cascades critical to T lymphocyte… Expand
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Highly Cited
1991
Highly Cited
1991
Production of synergistic but nonidentical mechanisms of immunosuppression by rapamycin and cyclosporine.
We report that the mechanism of rapamycin (RAP) inhibition is synergistic, but nonidentical, to the mechanism of CsA inhibition… Expand
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1991
1991
Failure of prolyl-peptidyl isomerase to mediate cyclosporine suppression of intracellular activation signal generation.
Cyclosporine blocks the generation of a cytoplasmic activation protein, activator of DNA replication (ADR). The recent… Expand
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1990
1990
A cytoplasmic activator of DNA replication is involved in signal transduction in antigen-specific T cell lines.
Cytoplasmic extracts prepared from T cell lines undergoing antigen-specific, interleukin-2 (IL-2)-dependent proliferation were… Expand
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1989
1989
Differences in the pattern of proliferative response with age in thymocytes undergoing spontaneous and induced proliferation.
The proliferative capacity of thymocytes from C3H/HeJ mice decrease as the animals attain maturity. The proliferative response of… Expand
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1986
1986
Impaired nuclear responsiveness to cytoplasmic signals in lymphocytes from elderly humans with depressed proliferative responses.
Lymphocytes from many elderly individuals exhibit depressed proliferative responses to the plant phytohemagglutinin (PHA). We… Expand
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