Zenarestat
National Institutes of Health
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Diabetes mellitus occurrence has been associated to the modification of the physiological levels of glucose and is often…
BACKGROUND
Polyneuropathy, a common complication of diabetes mellitus, causes pain and sensory and motor deficits in the limbs…
OBJECTIVE
The aim of this study was to report the baseline and natural progression of diabetic peripheral neuropathy over 12…
The crystal structure of the complex of human recombinant aldose reductase (AR) with zenarestat, one of its potent inhibitors…
We studied the effects of zenarestat, an aldose reductase inhibitor (ARI), on peripheral neuropathy in Zucker diabetic fatty (ZDF…
Objective: To determine whether the aldose reductase inhibitor (ARI) zenarestat improves nerve conduction velocity (NCV) and…
Abstract— Zenarestat, (3‐(4‐bromo‐2‐fluorobenzyl)‐7‐chloro‐2,4‐dioxo‐1,2,3,4‐tetrahydroquinazolin‐1‐y1) acetic acid, an aldose…
1. Rat shows a marked sex difference in the excretion of 14C-zenarestat: only 1% of the dose was excreted in the urine of males…