Zenarestat

Diabetes mellitus occurrence has been associated to the modification of the physiological levels of glucose and is often… Expand

The dorsal root ganglia (DRG) have been identified as the target tissue in diabetic somatosensory neuropathy. It has been… Expand

Conduct of a large, multicenter trial of the aldose reductase inhibitor zenarestat provided data on the reproducibility of… Expand

OBJECTIVE The aim of this study was to report the baseline and natural progression of diabetic peripheral neuropathy over 12… Expand

The crystal structure of the complex of human recombinant aldose reductase (AR) with zenarestat, one of its potent inhibitors… Expand

The effects of zenarestat, an aldose reductase inhibitor, on endoneurial blood flow (NBF) were explored in streptozotocin-induced… Expand

We studied the effects of zenarestat, an aldose reductase inhibitor (ARI), on peripheral neuropathy in Zucker diabetic fatty (ZDF… Expand

Objective: To determine whether the aldose reductase inhibitor (ARI) zenarestat improves nerve conduction velocity (NCV) and… Expand

Abstract— Zenarestat, (3‐(4‐bromo‐2‐fluorobenzyl)‐7‐chloro‐2,4‐dioxo‐1,2,3,4‐tetrahydroquinazolin‐1‐y1) acetic acid, an aldose… Expand

1. Rat shows a marked sex difference in the excretion of 14C-zenarestat: only 1% of the dose was excreted in the urine of males… Expand