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Zankiren
Known as:
(S)-N-((1S,2R,3S)-1-(Cyclohexylmethyl)-2,3-Dihydroxy-5-Methylhexyl)-Alpha((Alpha-S)-Alpha(((4-Methyl-1-Piperazinyl)Sulfonyl)Methyl)Hydrocinnamamido)-4-Thiazolepropionamide
, 4-Thiazolepropanamide, N-(1-(Cyclohexylmethyl)-2,3-Dihydroxy-5-Methylhexyl)-Alpha-((2-(((4-Methyl-1-Piperazinyl)Sulfonyl)Methyl)-1-Oxo-3-Phenylpropyl)Amino)-, (1S-(1R*,(R*(R*)),2S*,3R*))-
National Institutes of Health
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Elucidation of the binding mechanism of renin using a wide array of computational techniques and biological assays.
Haralambos Tzoupis
,
G. Leonis
,
+9 authors
M. Papadopoulos
Journal of molecular graphics & modelling
2015
Corpus ID: 4706737
Review
2012
Review
2012
Aliskiren, the first direct renin inhibitor for treatment of hypertension: the path of its development.
M. Jadhav
,
C. Yeola
,
G. Zope
,
A. Nabar
Journal of postgraduate medicine
2012
Corpus ID: 9808179
Standard treatments available today for treating hypertension is diuretics, β-blockers, angiotensin converting enzyme inhibitors…
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Highly Cited
2005
Highly Cited
2005
Aliskiren, a novel, orally effective renin inhibitor, lowers blood pressure in marmosets and spontaneously hypertensive rats
J. Wood
,
C. Schnell
,
F. Cumin
,
J. Ménard
,
R. Webb
Journal of hypertension
2005
Corpus ID: 43834984
Objectives Aliskiren is a new renin inhibitor of a novel structural class that has recently been shown to be efficacious in…
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1995
1995
Dose-dependent effects of the renin inhibitor zankiren HCl after a single oral dose in mildly sodium-depleted normotensive subjects.
J. Ménard
,
R. Boger
,
D. Moyse
,
T. Guyene
,
H. Glassman
,
H. Kleinert
Circulation
1995
Corpus ID: 6390019
BACKGROUND Zankiren HCl (A-72517) is a potent renin inhibitor shown to have substantial bioavailability in several animal species…
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1995
1995
Renal vascular responses to renin inhibition with zankiren in men
N. Fisher
,
Norman H. Hollenberg
Clinical pharmacology and therapeutics
1995
Corpus ID: 8696291
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