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- Bioorganic & medicinal chemistry letters
Z-Endoxifen is widely regarded as the most active metabolite of tamoxifen, and has recently demonstrated a 26.3% clinical benefit… (More)
Purpose Endoxifen is a tamoxifen metabolite with potent antiestrogenic activity. Patients and Methods We performed a phase I… (More)
The tamoxifen metabolite Z-endoxifen has acceptable tolerability and antitumor activity.
Z-endoxifen is the most potent of the metabolites of tamoxifen, and has the potential to be more effective than tamoxifen because… (More)
- Drug metabolism and pharmacokinetics
Genetic variations in cytochrome P450 2D6 (CYP2D6) contribute to interindividual variability in the metabolism of clinically used… (More)
The CYP3A and CYP2D6 enzymes play a major role in converting tamoxifen to its active metabolites. CYP3A is a highly… (More)
A new hydroxylated metabolite of tamoxifen, Metabolite Y [frans-1 -(p-/?-hydroxyethoxyphenyl)-1,2-diphenylbut-1-ene] was… (More)
DNA damage caused by tamoxifen and its derivatives was examined by estimating the conversion of supercoiled pUC18 plasmid DNA to… (More)
- European journal of cancer & clinical oncology
The metabolism of tamoxifen in the human has been well established and may be important in the antiestrogenic activity of this… (More)
A new hydroxylated metabolite of tamoxifen, Metabolite Y [trans-1-(p-beta-hydroxyethoxyphenyl)-1,2-diphenylbut-1-ene] was… (More)