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Z-Endoxifen Hydrochloride

Known as: 4-Hydroxy-N-Desmethyltamoxifen Hydrochloride, Z-Endoxifen HCl 
The hydrochloride salt and the z (cis-) stereoisomer of endoxifen with potential antineoplastic activity. Endoxifen, the active metabolite of… 
National Institutes of Health

Related topics

Related topics

1 relation
NCIt Antineoplastic Agent Terminology

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
CYP2D6 Genotype-Guided Tamoxifen Dosing in Hormone Receptor-Positive Metastatic Breast Cancer (TARGET-1): A Randomized, Open-Label, Phase II Study.
PURPOSE In patients taking tamoxifen, the CYP2D6 genotype causes different exposure of active metabolite endoxifen. The objective… 
2018
2018
Exploiting Pharmacokinetic Models of Tamoxifen and Endoxifen to Identify Factors Causing Subtherapeutic Concentrations in Breast Cancer Patients
Background and ObjectivesA better understanding of the highly variable pharmacokinetics (PK) of tamoxifen and its active… 
2018
2018
Curcumin for the Prevention of Epithelial-Mesenchymal Transition in Endoxifen-Treated MCF-7 Breast Cancer Cells
Background: Curcumin was shown to reduce epithelial-mesenchymal transition (EMT) markers in previous short term studies. This… 
2018
2018
A multi-gram-scale stereoselective synthesis of Z-endoxifen.
Highly Cited
2017
Highly Cited
2017
Serum concentrations of active tamoxifen metabolites predict long-term survival in adjuvantly treated breast cancer patients
BackgroundControversies exist as to whether the genetic polymorphisms of the enzymes responsible for the metabolism of tamoxifen… 
2017
2017
Utility of 18F-fluoroestradiol (18F-FES) PET/CT imaging as a pharmacodynamic marker in patients with refractory estrogen receptor-positive solid tumors receiving Z-endoxifen therapy
BackgroundZ-endoxifen is the most potent of the metabolites of tamoxifen, and has the potential to be more effective than… 
2017
2017
Fast and Adequate Liquid Chromatography–Tandem Mass Spectrometric Determination of Z-endoxifen Serum Levels for Therapeutic Drug Monitoring
Background: Z-endoxifen (further referred to as endoxifen, unless stated otherwise) is proposed as the most important metabolite… 
2016
2016
Linker design for the modular assembly of multifunctional and targeted platinum(ii)-containing anticancer agents.
A versatile and efficient modular synthetic platform was developed for assembling multifunctional conjugates and targeted forms… 
2014
2014
Pharmacokinetics of endoxifen and tamoxifen in female mice: implications for comparative in vivo activity studies
BackgroundReduced CYP2D6 metabolism and low Z-endoxifen (ENDX) concentrations may increase the risk of breast cancer recurrence… 
2013
2013
Endoxifen and Other Metabolites of Tamoxifen Inhibit Human Hydroxysteroid Sulfotransferase 2A1 (hSULT2A1)
Although tamoxifen is a successful agent for treatment and prevention of estrogen-dependent breast cancer, its use has been… 
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