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YM 298198

Known as: YM-298198, YM298198 
 

Topic mentions per year

Topic mentions per year

2005-2017
012320052017

Papers overview

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2017
2017
Cardiac mGluR1 metabotropic receptors in cardioprotection.
Aims In a previous study using a genome-wide microarray strategy, we identified metabotropic glutamate receptor 1 (mGluR1) as a… (More)
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2015
2015
Group I metabotropic glutamate receptor-mediated activation of PKC gamma in the nucleus accumbens core promotes the reinstatement of cocaine seeking.
Emerging evidence indicates that type I metabotropic glutamate receptors (mGluRs) in the nucleus accumbens play a critical role… (More)
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2013
2013
Stimulation of mGluR5 in the accumbens shell promotes cocaine seeking by activating PKC gamma.
Recent studies indicate a critical role for metabotropic glutamate receptor 5 (mGluR5) in the reinstatement of cocaine seeking… (More)
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2010
2010
The bidirectionality of motor learning in the vestibulo-ocular reflex is a function of cerebellar mGluR1 receptors.
Bidirectional changes in synaptic transmission have the potential to optimize the control of movement. However, it can be… (More)
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2010
2010
Pharmacological effects of metabotropic glutamate receptor ligands on prepulse inhibition in DBA/2J mice.
Schizophrenic patients typically exhibit impairment of sensorimotor gating, which can be modeled in animals using acoustic… (More)
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2009
2009
Identification of a novel transmembrane domain involved in the negative modulation of mGluR1 using a newly discovered allosteric mGluR1 antagonist, 3-cyclohexyl-5-fluoro-6-methyl-7-(2-morpholin-4…
Currently tested allosteric modulators for metabotropic glutamate receptor 1 (mGluR1) are known to regulate the activity of… (More)
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2009
2009
Non-competitive metabotropic glutamate 1 receptor antagonists block activity of slowly adapting type I mechanoreceptor units in the rat sinus hair follicle.
Previous studies suggested that Group I metabotropic glutamate (mGlu) receptors play a role in mechanotransduction processes of… (More)
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2007
2007
Potent and specific action of the mGlu1 antagonists YM-298198 and JNJ16259685 on synaptic transmission in rat cerebellar slices.
BACKGROUND AND PURPOSE Specific and selective inhibitors for mGlu1 receptors are presently inadequate. A new generation of non… (More)
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2007
2007
Synthesis and preliminary biological evaluation of 3-[(18)F]fluoro-5-(2-pyridinylethynyl)benzonitrile as a PET radiotracer for imaging metabotropic glutamate receptor subtype 5.
The metabotropic glutamate receptor subtype 5 (mGluR5) has been reported to be implicated in various neurological disorders in… (More)
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2005
2005
Radioligand binding properties and pharmacological characterization of 6-amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamide (YM-298198), a high-affinity, selective, and…
Metabotropic glutamate receptor type 1 (mGluR1) is thought to play important roles in the neurotransmission and pathogenesis of… (More)
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