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YM 298198

Known as: YM-298198, YM298198 
 
National Institutes of Health

Papers overview

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2017
2017
Cardiac mGluR1 metabotropic receptors in cardioprotection.
Aims In a previous study using a genome-wide microarray strategy, we identified metabotropic glutamate receptor 1 (mGluR1) as a… Expand
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2014
2014
Activation of lateral hypothalamic mGlu1 and mGlu5 receptors elicits feeding in rats
Metabotropic glutamate receptors (mGluRs) have been popular drug targets for a variety of central nervous system (CNS) disease… Expand
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2011
2011
Examination of a role for metabotropic glutamate receptor 5 in the medial prefrontal cortex in cocaine sensitization in rats
RationaleGlutamatergic projection neurons in the medial prefrontal cortex (mPFC) are hyperexcitable in cocaine-sensitized animals… Expand
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2010
2010
Evaluation of Cannabinoid Receptor 2 and Metabotropic Glutamate Receptor 1 Functional Responses Using a Cell Impedance–Based Technology
Recently, new technologies based on biosensors and called label free have been developed. These technologies eliminate the need… Expand
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2010
2010
Pharmacological effects of metabotropic glutamate receptor ligands on prepulse inhibition in DBA/2J mice.
Schizophrenic patients typically exhibit impairment of sensorimotor gating, which can be modeled in animals using acoustic… Expand
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2009
2009
Identification of a novel transmembrane domain involved in the negative modulation of mGluR1 using a newly discovered allosteric mGluR1 antagonist, 3-cyclohexyl-5-fluoro-6-methyl-7-(2-morpholin-4…
Currently tested allosteric modulators for metabotropic glutamate receptor 1 (mGluR1) are known to regulate the activity of… Expand
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2009
2009
Non-competitive metabotropic glutamate 1 receptor antagonists block activity of slowly adapting type I mechanoreceptor units in the rat sinus hair follicle
Previous studies suggested that Group I metabotropic glutamate (mGlu) receptors play a role in mechanotransduction processes of… Expand
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2007
2007
Potent and specific action of the mGlu1 antagonists YM-298198 and JNJ16259685 on synaptic transmission in rat cerebellar slices.
BACKGROUND AND PURPOSE Specific and selective inhibitors for mGlu1 receptors are presently inadequate. A new generation of non… Expand
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2007
2007
Synthesis and preliminary biological evaluation of 3-[(18)F]fluoro-5-(2-pyridinylethynyl)benzonitrile as a PET radiotracer for imaging metabotropic glutamate receptor subtype 5.
The metabotropic glutamate receptor subtype 5 (mGluR5) has been reported to be implicated in various neurological disorders in… Expand
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2005
2005
Radioligand binding properties and pharmacological characterization of 6-amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamide (YM-298198), a high-affinity, selective, and…
Metabotropic glutamate receptor type 1 (mGluR1) is thought to play important roles in the neurotransmission and pathogenesis of… Expand
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