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YM 244769

Known as: YM-244769, YM244769 
 
National Institutes of Health

Papers overview

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2017
2017
Chronic pharmacological blockade of the Na+/Ca2+ exchanger modulates the growth and development of the Purkinje cell dendritic arbor in mouse cerebellar slice cultures
The Na+ /Ca2+ exchanger (NCX) is a bidirectional plasma membrane antiporter involved in Ca2+ homeostasis in eukaryotes. NCX has… Expand
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2016
2016
Transient Oxygen/Glucose Deprivation Causes a Delayed Loss of Mitochondria and Increases Spontaneous Calcium Signaling in Astrocytic Processes
Recently, mitochondria have been localized to astrocytic processes where they shape Ca2+ signaling; this relationship has not… Expand
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2016
2016
Inhibitory effect of YM-244769, a novel Na+/Ca2+ exchanger inhibitor on Na+/Ca2+ exchange current in guinea pig cardiac ventricular myocytes
Recently, YM-244769 (N-(3-aminobenzyl)-6-{4-[(3-fluorobenzyl)oxy]phenoxy} nicotinamide) has been reported as a new potent and… Expand
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Highly Cited
2015
Highly Cited
2015
Reciprocal Regulation of Mitochondrial Dynamics and Calcium Signaling in Astrocyte Processes
We recently showed that inhibition of neuronal activity, glutamate uptake, or reversed-Na+/Ca2+-exchange with TTX, TFB-TBOA, or… Expand
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2014
2014
Ca2+ Influx via the Na+/Ca2+ Exchanger Is Enhanced in Malignant Hyperthermia Skeletal Muscle*
Background: Dysregulation of Ca2+ homeostasis have been described in malignant hyperthermia (MH). Results: Na+/Ca2+ exchanger… Expand
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2014
2014
Cardiac P2X purinergic receptors as a new pathway for increasing Na⁺ entry in cardiac myocytes.
P2X4 receptors (P2X4Rs) are ligand-gated ion channels capable of conducting cations such as Na(+). Endogenous cardiac P2X4R can… Expand
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2012
2012
Functional and morphological properties of pericytes in suburothelial venules of the mouse bladder.
BACKGROUND AND PURPOSE In suburothelial venules of rat bladder, pericytes (perivascular cells) develop spontaneous Ca(2… Expand
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2012
2012
Na(+) /Ca(2+) exchanger 2-heterozygote knockout mice display decreased acetylcholine release and altered colonic motility in vivo.
BACKGROUND The Na(+) /Ca(2+) exchanger (NCX) is a plasma membrane transporter involved in regulating intracellular Ca(2… Expand
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Review
2007
Review
2007
Na+/Ca2+ exchange as a drug target--insights from molecular pharmacology and genetic engineering.
  • Takahiro Iwamoto
  • Annals of the New York Academy of Sciences
  • 2007
    • Corpus ID: 3065022
The Na+/Ca2+ exchanger (NCX) is an ion transporter that exchanges Na+ and Ca2+ in either Ca2+-efflux or Ca2+-influx mode… Expand
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2006
2006
YM-244769, a Novel Na+/Ca2+ Exchange Inhibitor That Preferentially Inhibits NCX3, Efficiently Protects against Hypoxia/Reoxygenation-Induced SH-SY5Y Neuronal Cell Damage
We investigated the pharmacological properties and interaction domains of N-(3-aminobenzyl)-6-{4-[(3-fluorobenzyl)oxy]phenoxy… Expand
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