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YM 244769

Known as: YM-244769, YM244769 
National Institutes of Health

Papers overview

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2017
2017
Chronic pharmacological blockade of the Na+/Ca2+ exchanger modulates the growth and development of the Purkinje cell dendritic arbor in mouse cerebellar slice cultures
The Na+/Ca2+ exchanger (NCX) is a bidirectional plasma membrane antiporter involved in Ca2+ homeostasis in eukaryotes. NCX has… 
2017
2017
159 Trpm2 ion channel activation contributes to redox-sensitive vascular dysfunction in hypertension
The interplay between reactive oxygen species (ROS) and Ca2?+ plays a major role in the regulation of vascular function. However… 
2016
2016
Inhibitory effect of YM-244769, a novel Na+/Ca2+ exchanger inhibitor on Na+/Ca2+ exchange current in guinea pig cardiac ventricular myocytes
Recently, YM-244769 (N-(3-aminobenzyl)-6-{4-[(3-fluorobenzyl)oxy]phenoxy} nicotinamide) has been reported as a new potent and… 
2016
2016
Inhibitory effect of YM-244769, a novel Na+/Ca2+ exchanger inhibitor on Na+/Ca2+ exchange current in guinea pig cardiac ventricular myocytes
Recently, YM-244769 (N-(3-aminobenzyl)-6-{4-[(3-fluorobenzyl)oxy]phenoxy} nicotinamide) has been reported as a new potent and… 
2014
2014
Cardiac P2X purinergic receptors as a new pathway for increasing Na⁺ entry in cardiac myocytes.
P2X4 receptors (P2X4Rs) are ligand-gated ion channels capable of conducting cations such as Na(+). Endogenous cardiac P2X4R can… 
2014
2014
Skeletal Muscle Is Enhanced in Malignant Hyperthermia Exchanger 2 + / Ca + Influx via the Na 2 + Ca Membrane Biology :
2012
2012
Na+/Ca2+ exchanger 2‐heterozygote knockout mice display decreased acetylcholine release and altered colonic motility in vivo
Background  The Na+/Ca2+ exchanger (NCX) is a plasma membrane transporter involved in regulating intracellular Ca2… 
2012
2012
Electrophysiological properties of YM‐244769, a new and selective NCX blocker, in heart
A selective Na+/Ca2+ exchange (NCX) inhibitor would be very useful for studying both the physiological roles of NCX and a new… 
2006
2006
YM-244769, a Novel Na+/Ca2+ Exchange Inhibitor That Preferentially Inhibits NCX3, Efficiently Protects against Hypoxia/Reoxygenation-Induced SH-SY5Y Neuronal Cell Damage
We investigated the pharmacological properties and interaction domains of N-(3-aminobenzyl)-6-{4-[(3-fluorobenzyl)oxy]phenoxy… 
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