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YM 244769

Known as: YM-244769, YM244769 
 
National Institutes of Health

Papers overview

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2016
2016
Transient Oxygen/Glucose Deprivation Causes a Delayed Loss of Mitochondria and Increases Spontaneous Calcium Signaling in Astrocytic Processes
Recently, mitochondria have been localized to astrocytic processes where they shape Ca2+ signaling; this relationship has not… Expand
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2016
2016
Inhibitory effect of YM-244769, a novel Na+/Ca2+ exchanger inhibitor on Na+/Ca2+ exchange current in guinea pig cardiac ventricular myocytes
Recently, YM-244769 (N-(3-aminobenzyl)-6-{4-[(3-fluorobenzyl)oxy]phenoxy} nicotinamide) has been reported as a new potent and… Expand
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Highly Cited
2015
Highly Cited
2015
Reciprocal Regulation of Mitochondrial Dynamics and Calcium Signaling in Astrocyte Processes
We recently showed that inhibition of neuronal activity, glutamate uptake, or reversed-Na+/Ca2+-exchange with TTX, TFB-TBOA, or… Expand
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2015
2015
Genetic knockout and pharmacologic inhibition of NCX2 cause natriuresis and hypercalciuria.
The Na(+)/Ca(2+) exchanger (NCX) is a bidirectional transporter that is controlled by membrane potential and transmembrane… Expand
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2014
2014
Ca2+ Influx via the Na+/Ca2+ Exchanger Is Enhanced in Malignant Hyperthermia Skeletal Muscle*
Background: Dysregulation of Ca2+ homeostasis have been described in malignant hyperthermia (MH). Results: Na+/Ca2+ exchanger… Expand
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2014
2014
Cardiac P2X purinergic receptors as a new pathway for increasing Na⁺ entry in cardiac myocytes.
P2X4 receptors (P2X4Rs) are ligand-gated ion channels capable of conducting cations such as Na(+). Endogenous cardiac P2X4R can… Expand
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2012
2012
Functional and morphological properties of pericytes in suburothelial venules of the mouse bladder
In suburothelial venules of rat bladder, pericytes (perivascular cells) develop spontaneous Ca2+ transients, which may drive the… Expand
2012
2012
Na+/Ca2+ exchanger 2‐heterozygote knockout mice display decreased acetylcholine release and altered colonic motility in vivo
Background  The Na+/Ca2+ exchanger (NCX) is a plasma membrane transporter involved in regulating intracellular Ca2… Expand
Review
2007
Review
2007
Na+/Ca2+ Exchange as a Drug Target—Insights from Molecular Pharmacology and Genetic Engineering
  • T. Iwamoto
  • Annals of the New York Academy of Sciences
  • 2007
    • Corpus ID: 3065022
Abstract:  The Na+/Ca2+ exchanger (NCX) is an ion transporter that exchanges Na+ and Ca2+ in either Ca2+‐efflux or Ca2+‐influx… Expand
2006
2006
YM-244769, a Novel Na+/Ca2+ Exchange Inhibitor That Preferentially Inhibits NCX3, Efficiently Protects against Hypoxia/Reoxygenation-Induced SH-SY5Y Neuronal Cell Damage
We investigated the pharmacological properties and interaction domains of N-(3-aminobenzyl)-6-{4-[(3-fluorobenzyl)oxy]phenoxy… Expand
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