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YH 439

Known as: YH-439, YH439 
National Institutes of Health

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1 relation

Broader (1)

Thiazoles

Papers overview

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2014
2014
Nucleotide specificity of DNA binding of the aryl hydrocarbon receptor:ARNT complex is unaffected by ligand structure.
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates the toxic and biological effects of… 
2010
2010
Amino Acid Substitutions in the Aryl Hydrocarbon Receptor Ligand Binding Domain Reveal YH439 As an Atypical AhR Activator
The aryl hydrocarbon receptor (AhR) is traditionally defined as a transcription factor activated by exogenous polyaromatic and… 
2010
2010
Thermal reversible microemulsion system for poorly water-soluble YH439 for oral delivery.
To improve bioavailability of poorly water-soluble YH439, a thermal reversible microemulsion system was prepared using modified… 
1999
1999
Inhibitory effects of isopropyl-2-(1,3-dithietane-2-ylidene)-2- [N-(4-methylthiazol-2-yl)carbamoyl]acetate (YH439) on benzo[a]pyrene-induced skin carcinogenesis and micronucleated reticulocyte…
1998
1998
Species differences in pharmacokinetics of a hepatoprotective agent, YH439, and its metabolites, M4, M5, and M7, after intravenous and oral administration to rats, rabbits, and dogs.
Pharmacokinetic parameters of YH439 and its metabolites, M4, M5, and M7, were compared after iv administration of YH439 to rats… 
1996
1996
Transcriptional induction of the cytochrome P4501A1 gene by a thiazolium compound, YH439.
The molecular mechanism of induction of cytochromes P4501A1/2 (CYP1A1/2) by a synthetic compound YH439 was studied in rodents as… 
1996
1996
Transcriptional inhibition of cytochrome P4502E1 by a synthetic compound, YH439.
The molecular mechanism of cytochrome P4502E1 (CYP2E1) inhibition by a synthetic compound, YH439, was studied. In rats treated… 
1996
1996
Inhibition of covalent DNA binding and mutagenicity of benzo[a]pyrene by isopropyl-2-(1,3-dithietane-2-ylidene)-2-[N-(4-methylthiazol-2-yl) carbamoyl]acetate (YH439), a novel hepatoprotective agent.
1996
1996
Effect of a hepatoprotective agent, YH-439, on the pharmacokinetics of furosemide and azosemide in rats.
The effect of YH-439 pretreatment on the pharmacokinetics of furosemide and azosemide was investigated after intravenous (iv… 
1996
1996
Suppression of rat hepatic cytochrome P450 2E1 expression by isopropyl 2-(1,3-dithioetane-2-ylidene)-2-[N-(4-methyl-thiazol-2-yl)carbamoyl] acetate (YH439), an experimental hepatoprotectant…
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