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YH 439

Known as: YH-439, YH439 
 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

Thiazoles

Papers overview

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2014
2014
Nucleotide specificity of DNA binding of the aryl hydrocarbon receptor:ARNT complex is unaffected by ligand structure.
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates the toxic and biological effects of… Expand
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2010
2010
Thermal reversible microemulsion system for poorly water-soluble YH439 for oral delivery.
To improve bioavailability of poorly water-soluble YH439, a thermal reversible microemulsion system was prepared using modified… Expand
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2010
2010
Amino Acid Substitutions in the Aryl Hydrocarbon Receptor Ligand Binding Domain Reveal YH439 As an Atypical AhR Activator
The aryl hydrocarbon receptor (AhR) is traditionally defined as a transcription factor activated by exogenous polyaromatic and… Expand
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Highly Cited
2001
Highly Cited
2001
Acetaminophen induces apoptosis of C6 glioma cells by activating the c-Jun NH(2)-terminal protein kinase-related cell death pathway.
Acetaminophen (AAP), a widely used analgesic drug, can damage various organs when taken in large doses. In this study, we… Expand
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2000
2000
Cytochrome P450 2E1 (CYP2E1)-dependent production of a 37-kDa acetaldehyde-protein adduct in the rat liver.
Ethanol-inducible cytochrome P450 2E1 (CYP2E1) has been shown to be involved in the metabolism of both ethanol and acetaldehyde… Expand
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1999
1999
Inhibitory effects of isopropyl-2-(1,3-dithietane-2-ylidene)-2- [N-(4-methylthiazol-2-yl)carbamoyl]acetate (YH439) on benzo[a]pyrene-induced skin carcinogenesis and micronucleated reticulocyte…
Recently, a great deal of attention has been devoted to organosulfur compounds with potential cancer chemopreventive properties… Expand
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1998
1998
Species differences in pharmacokinetics of a hepatoprotective agent, YH439, and its metabolites, M4, M5, and M7, after intravenous and oral administration to rats, rabbits, and dogs.
Pharmacokinetic parameters of YH439 and its metabolites, M4, M5, and M7, were compared after iv administration of YH439 to rats… Expand
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1998
1998
Hepatic and intestinal first-pass effects of a new hepatoprotective agent, YH439, in rats.
First-pass effects of YH439 were evaluated after intravenous, intraportal, oral, and intraduodenal administration of the drug… Expand
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1996
1996
Transcriptional induction of the cytochrome P4501A1 gene by a thiazolium compound, YH439.
The molecular mechanism of induction of cytochromes P4501A1/2 (CYP1A1/2) by a synthetic compound YH439 was studied in rodents as… Expand
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1996
1996
Transcriptional inhibition of cytochrome P4502E1 by a synthetic compound, YH439.
The molecular mechanism of cytochrome P4502E1 (CYP2E1) inhibition by a synthetic compound, YH439, was studied. In rats treated… Expand
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