YH 439

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that mediates the toxic and biological effects of… (More)

The aryl hydrocarbon receptor (AhR) is traditionally defined as a transcription factor activated by exogenous polyaromatic and… (More)

Acetaminophen (AAP), a widely used analgesic drug, can damage various organs when taken in large doses. In this study, we… (More)

Ethanol-inducible cytochrome P450 2E1 (CYP2E1) has been shown to be involved in the metabolism of both ethanol and acetaldehyde… (More)

Recently, a great deal of attention has been devoted to organosulfur compounds with potential cancer chemopreventive properties… (More)

First-pass effects of YH439 were evaluated after intravenous, intraportal, oral, and intraduodenal administration of the drug… (More)

The molecular mechanism of induction of cytochromes P4501A1/2 (CYP1A1/2) by a synthetic compound YH439 was studied in rodents as… (More)

Isopropyl-2-(1,3-dithietane-2-ylidene)-2[N-(4-methyl-2-thiazol+ ++-2-yl) carbamoyl]acetate (YH439) was synthesized as a… (More)

The molecular mechanism of cytochrome P4502E1 (CYP2E1) inhibition by a synthetic compound, YH439, was studied. In rats treated… (More)

Various factors influencing the plasma protein binding of YH-439 to 4% human serum albumin (HSA) were evaluated using the… (More)