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YH 439

Known as: YH-439, YH439 
National Institutes of Health

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1 relation

Broader (1)

Thiazoles

Papers overview

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2010
2010
Thermal reversible microemulsion system for poorly water-soluble YH439 for oral delivery.
To improve bioavailability of poorly water-soluble YH439, a thermal reversible microemulsion system was prepared using modified… 
2005
2005
Effect of a new hepatoprotective agent, YH-439, on the hepatobiliary transport of organic cations (OCS): Selective inhibition of sinusoidal OCs uptake without influencing glucose uptake and…
The effect of a new hepatoprotective agent, YH-439, on the hepatobiliary transport of a model organic cation (OC), TBuMA… 
2001
2001
The transport of a hepatoprotective agent, isopropryl 2-(1-3-dithiethane-2-ylidene)-2[N-(4-methyl-th iazole-2-yl) carbamoyl] acetate (YH439), across caco-2 cell monolayers
Isopropryl 2-(1-3-dithiethane-2-ylidene)-2[N-(4-methyl-thiazole-2-yl) carbamoyl] acetate (YH439) is currently under phase II… 
1998
1998
Hepatic and intestinal first-pass effects of a new hepatoprotective agent, YH439, in rats.
First-pass effects of YH439 were evaluated after intravenous, intraportal, oral, and intraduodenal administration of the drug… 
1998
1998
Inhibition of vinyl carbamate-induced hepatotoxicity, mutagenicity, and tumorigenicity by isopropyl-2-(1,3-dithietane-2-ylidene)-2-[N-(4-methylthiazol-2- yl)carbamoyl]acetate (YH439).
Isopropyl-2-(1,3-dithietane-2-ylidene)-2-[N-(4-methylthiazol -2-yl)carbamoyl]acetate (YH439) is a novel dithioylidene malonate… 
1998
1998
Use of 99mTc-mercaptoacetyltriglycine (MAG3)-biocytin hepatobiliary scintigraphy to study the protective effect of a synthetic enzyme inhibitor on acute hepatotoxicity in mice.
1998
1998
Simultaneous determination of a new hepatoprotective agent, YH439, and its metabolites, M4, M5, and M7 in plasma and urine by high-performance liquid chromatography.
A high-performance liquid chromatographic method was developed for the simultaneous determination of YH439, and its metabolites… 
1996
1996
Effect of a hepatoprotective agent, YH-439, on the pharmacokinetics of furosemide and azosemide in rats.
The effect of YH-439 pretreatment on the pharmacokinetics of furosemide and azosemide was investigated after intravenous (iv… 
1996
1996
Metabolic changes of acetaminophen after intravenous administration to rats pretreated with a hepatoprotective agent, YH-439.
The metabolic changes of acetaminophen (AAP) were investigated after the intravenous (iv) administration of AAP, 300 mg per kg… 
1995
1995
Factors influencing the protein binding of YH‐439 using an equilibrium dialysis technique. A new hepatoprotective agent
Various factors influencing the plasma protein binding of YH‐439 to 4% human serum albumin (HSA) were evaluated using the… 
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