Y-39983
National Institutes of Health
Papers overview
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Purpose
To discover novel therapies that lower IOP by increasing aqueous humor outflow facility, ex vivo ocular perfusion systems…
PURPOSE
To investigate the molecular mechanism of Rho-associated kinase (ROCK) inhibitors Y-27632 and Y-39983 on corneal…
PURPOSE
To determine whether ROCK inhibition for the treatment of glaucoma can be improved by using novel, locally acting Rho…
Y-39983, a selective Rho-associated kinase (ROCK) inhibitor, promotes axonal regeneration of damaged retinal ganglion…
Objective: Rho-associated kinase (ROCK) is a serine/threonine kinase and a major downstream effector of the small GTP-binding…
PurposeIn normotensive eyes, reduced ocular blood flow can lead to glaucoma pathogenesis. Drugs that reduce intraocular pressure…
Purpose: To investigate the effects of Y-39983, a selective Rho-associated coiled coil-forming protein kinase inhibitor, on blood…
Purpose The outflow facility for aqueous humor across the trabecular meshwork (TM) is enhanced by agents that oppose the…
PURPOSE
Goals of this study were to determine if pharmacological or genetic inhibition of Rho-associated coiled coil containing…