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Xeroderma pigmentosum, group A

Known as: XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP A, XP1, Xeroderma Pigmentosum Group A 
National Institutes of Health

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9 relations
Basal cell carcinomaCutaneous MelanomaERCC3 protein, humanIntegumentary system

Papers overview

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2011
2011
XPA-Mediated Regulation of Global Nucleotide Excision Repair by ATR Is p53-Dependent and Occurs Primarily in S-Phase
Cell cycle checkpoints play an important role in regulation of DNA repair pathways. However, how the regulation occurs throughout… 
Review
2008
Review
2008
XPA gene, its product and biological roles.
The 31 kDa XPA protein is part of the core incision complex of the mammalian nucleotide excision repair (NER) system and… 
2007
2007
The ING1b tumor suppressor facilitates nucleotide excision repair by promoting chromatin accessibility to XPA.
2004
2004
Brainstem and Basal Ganglia Lesions in Xeroderma Pigmentosum Group A
Xeroderma pigmentosum group A (XPA) is a hereditary disorder characterized by cutaneous symptoms and progressive… 
2004
2004
Role of nucleotide- and base-excision repair in genotoxin-induced neuronal cell death.
2001
2001
A truncated human xeroderma pigmentosum complementation group A protein expressed from an adenovirus sensitizes human tumor cells to ultraviolet light and cisplatin.
Individuals with the genetic disease xeroderma pigmentosum (XP) have impaired nucleotide excision repair (NER). Group A XP cells… 
2001
2001
DNA-XPA interactions: a (31)P NMR and molecular modeling study of dCCAATAACC association with the minimal DNA-binding domain (M98-F219) of the nucleotide excision repair protein XPA.
Recent NMR-based, chemical shift mapping experiments with the minimal DNA-binding domain of XPA (XPA-MBD: M98-F219) suggest that… 
1999
1999
Resonance assignments, solution structure, and backbone dynamics of the DNA- and RPA-binding domain of human repair factor XPA.
XPA is involved in the damage recognition step of nucleotide excision repair (NER). XPA binds to other repair factors, and acts… 
Highly Cited
1997
Highly Cited
1997
Induction of DNA adducts and mutations in spleen, liver and lung of XPA-deficient/lacZ transgenic mice after oral treatment with benzo[a]pyrene: correlation with tumour development.
We were interested to study the relationship between DNA lesions, DNA repair, mutation fixation, and tumour development… 
Highly Cited
1996
Highly Cited
1996
Enhanced inflammation and immunosuppression by ultraviolet radiation in xeroderma pigmentosum group A (XPA) model mice.
Xeroderma pigmentosum group A (XPA) gene-deficient mice were developed by gene targeting in mouse embryonic stem cells. To… 
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