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XL281

Known as: RAF Kinase Inhibitor XL281 
An orally active, small molecule with potential antineoplastic activity. XL281 specifically inhibits RAF kinases, located downstream from RAS in the… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
PLX4032 (RG7204), a selective mutant RAF inhibitor: Clinical and histologic characteristics of therapy-associated cutaneous neoplasms in a phase I trial.
8592 Background: Tumor regressions have been observed in a significant proportion of advanced melanoma patients treated with… 
Review
2010
Review
2010
Anticipating drug resistance in the MAP kinase pathway
Kinases have become one of the most important families of drug targets for many diseases and for cancer in particular (Zhang et… 
2009
2009
Market watch: Sales from licensed and acquired products to increase by 2013
AVos Life sciences has analysed the revenue contribution of organically developed, licensed or co-developed, acquired and joint… 
2009
2009
Deal watch: Bristol–Myers Squibb and Exelixis collaborate on kinase inhibitors
2008
2008
383 POSTER A phase 1 study of XL281, a potent and selective inhibitor of RAF kinases, administered orally to patients (pts) with advanced solid tumors
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