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XL281
Known as:
RAF Kinase Inhibitor XL281
An orally active, small molecule with potential antineoplastic activity. XL281 specifically inhibits RAF kinases, located downstream from RAS in the…
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National Institutes of Health
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2016
Review
2016
Mutant B-Raf Kinase Inhibitors as Anticancer Agents.
Vivek Asati
,
S. Bharti
,
Debarshi Kar Mahapatra
Anti-Cancer Agents in Medicinal Chemistry
2016
Corpus ID: 37985894
The Ras/Raf/MEK/ERK signaling pathway involves various kinases in which each kinase is associated with one another through…
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2015
2015
Clinico‐morphological features of BRAF inhibition–induced proliferative skin lesions in cancer patients
V. R. Belum
,
A. Rosen
,
+7 authors
M. Lacouture
Cancer
2015
Corpus ID: 5420275
The use of BRAF inhibitors may lead to the development of cutaneous toxicities such as rashes, photosensitivity, alopecia…
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2015
2015
Phase I study of XL281 (BMS-908662), a potent oral RAF kinase inhibitor, in patients with advanced solid tumors
M. Dickson
,
M. Gordon
,
+6 authors
G. Schwartz
Investigational new drugs
2015
Corpus ID: 24064266
SummaryBackground XL281 is a potent and selective inhibitor of wild-type and mutant RAF kinases with anti-tumor activity in…
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Review
2013
Review
2013
B-Raf and the inhibitors: from bench to bedside
Tiangui Huang
,
M. Karsy
,
J. Zhuge
,
Minghao Zhong
,
Delong Liu
Journal of Hematology & Oncology
2013
Corpus ID: 262318294
The B-Raf protein is a key signaling molecule in the mitogen activated protein kinase (MAPK) signaling pathway and has been…
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2010
2010
PLX4032 (RG7204), a selective mutant RAF inhibitor: Clinical and histologic characteristics of therapy-associated cutaneous neoplasms in a phase I trial.
M. Lacouture
,
G. McArthur
,
+7 authors
J. Sosman
2010
Corpus ID: 79388140
8592 Background: Tumor regressions have been observed in a significant proportion of advanced melanoma patients treated with…
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Review
2010
Review
2010
Anticipating drug resistance in the MAP kinase pathway
R. Marmorstein
Pigment Cell & Melanoma Research
2010
Corpus ID: 46323893
Kinases have become one of the most important families of drug targets for many diseases and for cancer in particular (Zhang et…
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Highly Cited
2009
Highly Cited
2009
A phase I study of XL281, a selective oral RAF kinase inhibitor, in patients (Pts) with advanced solid tumors.
G. Schwartz
,
S. Robertson
,
+6 authors
M. Gordon
Journal of Clinical Oncology
2009
Corpus ID: 262274
3513 Background: XL281 is a potent and selective inhibitor of wild type and mutant RAF kinases showing anti-tumor activity in…
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2009
2009
Market watch: Sales from licensed and acquired products to increase by 2013
Michael Goodman
Nature reviews. Drug discovery
2009
Corpus ID: 27169850
AVos Life sciences has analysed the revenue contribution of organically developed, licensed or co-developed, acquired and joint…
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2009
2009
Deal watch: Bristol–Myers Squibb and Exelixis collaborate on kinase inhibitors
Nature reviews. Drug discovery
2009
Corpus ID: 30858859
2008
2008
383 POSTER A phase 1 study of XL281, a potent and selective inhibitor of RAF kinases, administered orally to patients (pts) with advanced solid tumors
G. Schwartz
,
S. Yazji
,
+6 authors
M. Gordon
2008
Corpus ID: 71454650
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