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XL184

An orally bioavailable, small molecule receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. XL184 strongly binds to and… Expand
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
BACKGROUND Cabozantinib targets tyrosine kinases including the hepatocyte growth factor receptor (MET) and vascular endothelial… Expand
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Highly Cited
2014
Highly Cited
2014
Purpose: ROS1 rearrangement leads to constitutive ROS1 activation with potent transforming activity. In an ongoing phase I trial… Expand
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Highly Cited
2013
Highly Cited
2013
Cabozantinib (XL184) is an oral multiple receptor tyrosine kinase inhibitor manufactured by Exelixis Inc., CA, USA. It mainly… Expand
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2013
2013
BACKGROUND A limited number of approved therapeutic options are available to metastatic medullary thyroid cancer (MTC) patients… Expand
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2012
2012
261 Background: Cabozantinib is an oral, potent inhibitor of MET and VEGFR2. MET over-expression has been observed in advanced… Expand
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Highly Cited
2011
Highly Cited
2011
The signaling pathway of the receptor tyrosine kinase MET and its ligand hepatocyte growth factor (HGF) is important for cell… Expand
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Highly Cited
2011
Highly Cited
2011
BACKGROUND & AIMS Growth of many different tumor types requires a population of self-renewing cancer stem cells (CSCs). c-Met is… Expand
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Highly Cited
2011
Highly Cited
2011
CONTEXT Medullary and papillary thyroid carcinoma (MTC and PTC) are two types of thyroid cancer that can originate from… Expand
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Highly Cited
2010
Highly Cited
2010
3017 Background: MET and VEGF play important roles in the pathobiology of NSCLC, and are associated with resistance to E. XL184… Expand
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Highly Cited
2008
Highly Cited
2008
3522 Background: XL184 is an orally bioavailable inhibitor of RET, MET & VEGFR2. XL184 strongly inhibits cell proliferation in… Expand
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