Skip to search formSkip to main contentSkip to account menu

XIAP/cIAP1 Antagonist ASTX660

Known as: ASTX 660, ASTX660 
An orally bioavailable, non-peptidomimetic antagonist of both X chromosome-linked inhibitor of apoptosis protein (XIAP) and cellular IAP 1 (cIAP1… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
PS1073 PRELIMINARY RESULTS OF ASTX660, A NOVEL NON-PEPTIDOMIMETIC CIAP1/2 AND XIAP ANTAGONIST, IN RELAPSED/REFRACTORY PERIPHERAL T-CELL LYMPHOMA AND CUTANEOUS T CELL LYMPHOMA
2018
2018
Abstract A091: Phase 1 study of IAP inhibitor ASTX660 in adults with advanced cancers and lymphomas
Background: We report dose escalation results from a phase 1/2 trial of ASTX660 (NCT02503423). This non-peptidomimetic, dual XIAP… 
2018
2018
Abstract 4399: Entinostat sensitizes colorectal cancer cell lines to the IAP antagonist, ASTX660 by down-regulating FLIP expression
Introduction Inhibitor of Apoptosis Proteins (IAPs) are anti-apoptotic proteins which suppress the activation of caspases. IAPs… 
2017
2017
Abstract 2016: Novel dual cIAP1/XIAP antagonist ASTX660 activity in preclinical models of human papillomavirus(+) and (-) head and neck squamous cell carcinoma
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer with a five-year survival of ~50%. HNSCC are linked… 
2016
2016
Abstract 1287: The dual IAP antagonist, ASTX660, increases the anti-tumor activity of paclitaxel in preclinical models of triple-negative breast cancer in vivo
Background: Paclitaxel-mediated secretion of inflammatory mediators, including TNFα, potentially creates paracrine and autocrine… 
2015
2015
cIAP 2 supports viability of mice lacking cIAP 1 and XIAP
I nitially classified as potent suppressors of programed cell death, members of the inhibitor of apoptosis (IAP) family have… 
2008
2008
Carcinoma colo-retal: relação entre a imuno-expressão das proteínas inibidoras da apoptose IAPS (Survivina, XIAP,cIAP1 e cIAP2) e seu antagonista Smac/DIABLO. correlação com índice apoptótico…
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)