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WIPI2 gene

Known as: CGI-50, WD repeat domain, phosphoinositide interacting 2, DKFZP434J154 
 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
PI3P binding by Atg21 organises Atg8 lipidation.
Autophagosome biogenesis requires two ubiquitin-like conjugation systems. One couples ubiquitin-like Atg8 to… Expand
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2015
2015
Characterization of PROPPIN-Phosphoinositide Binding and Role of Loop 6CD in PROPPIN-Membrane Binding.
PROPPINs (β-propellers that bind polyphosphoinositides) are a family of PtdIns3P- and PtdIns(3,5)P2-binding proteins that play an… Expand
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2014
2014
What causes grief in dementia caregivers?
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in the world. Most AD patients become dependent on their… Expand
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Highly Cited
2013
Highly Cited
2013
Regulation of nutrient-sensitive autophagy by uncoordinated 51-like kinases 1 and 2
Macroautophagy, commonly referred to as autophagy, is a protein degradation pathway that occurs constitutively in cells, but can… Expand
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Highly Cited
2012
Highly Cited
2012
Structural and functional characterization of the two phosphoinositide binding sites of PROPPINs, a β-propeller protein family
β-propellers that bind polyphosphoinositides (PROPPINs), a eukaryotic WD-40 motif-containing protein family, bind via their… Expand
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Highly Cited
2010
Highly Cited
2010
Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation
Autophagosome formation is a complex process that begins with the nucleation of a pre-autophagosomal structure (PAS) that expands… Expand
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Highly Cited
2010
Highly Cited
2010
Roles of the Lipid-binding Motifs of Atg18 and Atg21 in the Cytoplasm to Vacuole Targeting Pathway and Autophagy*
Atg18 and Atg21 are homologous WD-40 repeat proteins that bind phosphoinositides via a novel conserved Phe-Arg-Arg-Gly motif and… Expand
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Highly Cited
2006
Highly Cited
2006
The relevance of the phosphatidylinositolphosphat-binding motif FRRGT of Atg18 and Atg21 for the Cvt pathway and autophagy.
Atg18 and Atg21 are homologous S. cerevisiae autophagy proteins. Atg18 is essential for biogenesis of Cvt vesicles and… Expand
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2004
2004
Atg21 Is Required for Effective Recruitment of Atg8 to the Preautophagosomal Structure during the Cvt Pathway*
Atg21 and Atg18 are homologue yeast proteins. Whereas Atg18 is essential for the Cvt pathway and autophagy, a lack of Atg21 only… Expand
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Highly Cited
2004
Highly Cited
2004
Atg21 is a phosphoinositide binding protein required for efficient lipidation and localization of Atg8 during uptake of aminopeptidase I by selective autophagy.
Delivery of proteins and organelles to the vacuole by autophagy and the cytoplasm to vacuole targeting (Cvt) pathway involves… Expand
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