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WIPI2 gene

Known as: CGI-50, WD repeat domain, phosphoinositide interacting 2, DKFZP434J154 
National Institutes of Health

Papers overview

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Highly Cited
2019
Highly Cited
2019
Distinct functions of ATG16L1 isoforms in membrane binding and LC3B lipidation in autophagy-related processes
Covalent modification of LC3 and GABARAP proteins to phosphatidylethanolamine in the double-membrane phagophore is a key event in… 
Highly Cited
2015
Highly Cited
2015
PI3P binding by Atg21 organises Atg8 lipidation
Autophagosome biogenesis requires two ubiquitin‐like conjugation systems. One couples ubiquitin‐like Atg8 to… 
Highly Cited
2013
Highly Cited
2013
Regulation of nutrient-sensitive autophagy by uncoordinated 51-like kinases 1 and 2
Macroautophagy, commonly referred to as autophagy, is a protein degradation pathway that occurs constitutively in cells, but can… 
Highly Cited
2012
Highly Cited
2012
Structural and functional characterization of the two phosphoinositide binding sites of PROPPINs, a β-propeller protein family
β-propellers that bind polyphosphoinositides (PROPPINs), a eukaryotic WD-40 motif-containing protein family, bind via their… 
Highly Cited
2010
Highly Cited
2010
Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation
Autophagosome formation is a complex process that begins with the nucleation of a pre-autophagosomal structure (PAS) that expands… 
Highly Cited
2010
Highly Cited
2010
Roles of the Lipid-binding Motifs of Atg18 and Atg21 in the Cytoplasm to Vacuole Targeting Pathway and Autophagy*
Atg18 and Atg21 are homologous WD-40 repeat proteins that bind phosphoinositides via a novel conserved Phe-Arg-Arg-Gly motif and… 
Highly Cited
2008
Highly Cited
2008
Dissecting the localization and function of Atg18, Atg21 and Ygr223c
Atg18p and Atg21p are two highly homologous yeast autophagy proteins. Atg18p functions in both autophagy and the selective Cvt… 
Highly Cited
2006
Highly Cited
2006
The relevance of the phosphatidylinositolphosphat‐binding motif FRRGT of Atg18 and Atg21 for the Cvt pathway and autophagy
Highly Cited
2004
Highly Cited
2004
Atg21 is a phosphoinositide binding protein required for efficient lipidation and localization of Atg8 during uptake of aminopeptidase I by selective autophagy.
Delivery of proteins and organelles to the vacuole by autophagy and the cytoplasm to vacuole targeting (Cvt) pathway involves… 
Highly Cited
2004
Highly Cited
2004
Atg21 Is Required for Effective Recruitment of Atg8 to the Preautophagosomal Structure during the Cvt Pathway*
Atg21 and Atg18 are homologue yeast proteins. Whereas Atg18 is essential for the Cvt pathway and autophagy, a lack of Atg21 only… 
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