FAQ

WASH complex

Known as: WASH complex location 
A protein complex that localizes at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization. In… (More)

Topic mentions per year

Topic mentions per year

2009-2017
0246820092017

Papers overview

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Highly Cited
2014
Highly Cited
2014
Mutation in VPS35 associated with Parkinson’s disease impairs WASH complex association and inhibits autophagy
Endosomal protein sorting controls the localization of many physiologically important proteins and is linked to several… (More)
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2014
2014
Retromer Binding to FAM21 and the WASH Complex Is Perturbed by the Parkinson Disease-Linked VPS35(D620N) Mutation
Retromer is a protein assembly that plays a central role in orchestrating export of transmembrane-spanning cargo proteins from… (More)
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2014
2014
RME-8 coordinates the activity of the WASH complex with the function of the retromer SNX dimer to control endosomal tubulation.
Retromer is a vital element of the endosomal protein sorting machinery and comprises two subcomplexes that operate together to… (More)
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2013
2013
Endosomal recruitment of the WASH complex: active sequences and mutations impairing interaction with the retromer.
BACKGROUND INFORMATION The Wiskott-Aldrich syndrome protein and scar homolog (WASH) complex is the major Arp2/3 activator at the… (More)
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2013
2013
Cyclical action of the WASH complex: FAM21 and capping protein drive WASH recycling, not initial recruitment.
WASH causes actin to polymerize on vesicles involved in retrograde traffic and exocytosis. It is found within a regulatory… (More)
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2013
2013
The WASH complex, an endosomal Arp2/3 activator, interacts with the Hermansky–Pudlak syndrome complex BLOC-1 and its cargo phosphatidylinositol-4-kinase type IIα
Vesicle biogenesis machinery components such as coat proteins can interact with the actin cytoskeleton for cargo sorting into… (More)
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2013
2013
The hereditary spastic paraplegia protein strumpellin: Characterisation in neurons and of the effect of disease mutations on WASH complex assembly and function
Mutations in the gene encoding strumpellin cause autosomal dominant hereditary spastic paraplegia (HSP), in which there is… (More)
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Highly Cited
2012
Highly Cited
2012
Recruitment of the endosomal WASH complex is mediated by the extended 'tail' of Fam21 binding to the retromer protein Vps35.
The retromer complex is a conserved endosomal protein sorting complex that sorts membrane proteins into nascent endosomal tubules… (More)
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2011
2011
Identification of a novel candidate gene for non-syndromic autosomal recessive intellectual disability: the WASH complex member SWIP.
High-throughput sequencing has greatly facilitated the elucidation of genetic disorders, but compared with X-linked and autosomal… (More)
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Highly Cited
2009
Highly Cited
2009
A FAM21-containing WASH complex regulates retromer-dependent sorting.
The Arp2/3 complex regulates endocytosis, sorting, and trafficking, yet the Arp2/3-stimulating factors orchestrating these… (More)
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