Velcade
National Institutes of Health
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Amyloid diseases in man are caused by as many as 23 different pre-cursor proteins already described. Cardiologists predominantly…
Abstract 131
Introduction. Autologous stem cell transplantation (ASCT) after cytoreductive induction is considered standard of…
Introduction. ASCT is considered the standard of care for younger patients (pts) with MM. The benefit of ASCT is at least partly…
Proteasome inhibition results in proapoptotic changes in cancer cells, which may make them more sensitive to immune effector…
INTRODUCTION: A 2-arm Phase I/II trial was initiated to determine activity and toxicities of the VTD combination in patients with…
Normal cellular functioning requires processing of proteins regulating cell cycle, growth, and apoptosis. The ubiquitin…
Abstract Introduction: Bortezomib, a first in class proteasome inhibitor, has become a standard of care in the treatment of…
The combination of thalidomide and dexamethasone (TD) has induced disease remission in 69% of 132 newly diagnosed patients with…
Targeting the ubiquitin-proteasome pathway has emerged as a promising approach for treating cancer. Bortezomib (VELCADETM…