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VU0467154

 
National Institutes of Health

Papers overview

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2020
2020
BACKGROUND Alcohol use disorder (AUD) is a major socioeconomic burden on society, and current pharmacotherapeutic treatment… Expand
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2019
2019
The chronic pain and opioid epidemics have created an urgent need for effective, non-opioid analgesics. There is considerable… Expand
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2018
2018
ABSTRACT Although selective activation of the M1 muscarinic acetylcholine receptor (mAChR) subtype has been shown to improve… Expand
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2017
2017
This letter describes the chemical optimization of a novel series of M4 positive allosteric modulators (PAMs) based on a 5-amino… Expand
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2017
2017
BACKGROUND Cocaine addiction is a chronic brain disease affecting neurotransmission. Muscarinic cholinergic receptors modulate… Expand
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2016
2016
Accumulating evidence indicates direct relationships between sleep abnormalities and the severity and prevalence of other symptom… Expand
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2014
2014
Positive allosteric modulators (PAMs) of the M4 muscarinic acetylcholine receptor (mAChR) represent a novel approach for the… Expand
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2014
2014
Many symptoms in schizophrenia are attributed to alternations in normal glutamatergic signaling in the prefrontal cortex (PFC… Expand
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