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VU0467154

 

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Topic mentions per year

2014-2018
0120142018

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2018
2018
Cognitive enhancement and antipsychotic-like activity following repeated dosing with the selective M4 PAM VU0467154.
Although selective activation of the M1 muscarinic acetylcholine receptor (mAChR) subtype has been shown to improve cognitive… (More)
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2017
2017
Challenges in the development of an M4 PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogs.
This letter describes the chemical optimization of a novel series of M4 positive allosteric modulators (PAMs) based on a 5-amino… (More)
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2017
2017
Muscarinic receptor M4 positive allosteric modulators attenuate central effects of cocaine.
BACKGROUND Cocaine addiction is a chronic brain disease affecting neurotransmission. Muscarinic cholinergic receptors modulate… (More)
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2016
2016
State-dependent alterations in sleep/wake architecture elicited by the M4 PAM VU0467154 - Relation to antipsychotic-like drug effects.
Accumulating evidence indicates direct relationships between sleep abnormalities and the severity and prevalence of other symptom… (More)
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2014
2014
Selective Activation of M4 Muscarinic Acetylcholine Receptors Reverses MK-801-Induced Behavioral Impairments and Enhances Associative Learning in Rodents
Positive allosteric modulators (PAMs) of the M4 muscarinic acetylcholine receptor (mAChR) represent a novel approach for the… (More)
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