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VU0467154

 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Acetylcholine Muscarinic M4 Receptors as a Therapeutic Target for Alcohol Use Disorder: Converging Evidence From Humans and Rodents
BACKGROUND Alcohol use disorder (AUD) is a major socioeconomic burden on society, and current pharmacotherapeutic treatment… Expand
2019
2019
373) Muscarinic M4 Positive Allosteric Modulators are Antinociceptive in Mouse Inflammatory Pain Models
The chronic pain and opioid epidemics have created an urgent need for effective, non-opioid analgesics. There is considerable… Expand
2018
2018
Cognitive enhancement and antipsychotic-like activity following repeated dosing with the selective M4 PAM VU0467154
ABSTRACT Although selective activation of the M1 muscarinic acetylcholine receptor (mAChR) subtype has been shown to improve… Expand
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2017
2017
Challenges in the development of an M4 PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogs.
This letter describes the chemical optimization of a novel series of M4 positive allosteric modulators (PAMs) based on a 5-amino… Expand
2017
2017
Muscarinic receptor M4 positive allosteric modulators attenuate central effects of cocaine.
BACKGROUND Cocaine addiction is a chronic brain disease affecting neurotransmission. Muscarinic cholinergic receptors modulate… Expand
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2016
2016
State-dependent alterations in sleep/wake architecture elicited by the M4 PAM VU0467154 – Relation to antipsychotic-like drug effects
Accumulating evidence indicates direct relationships between sleep abnormalities and the severity and prevalence of other symptom… Expand
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Highly Cited
2014
Highly Cited
2014
Selective Activation of M4 Muscarinic Acetylcholine Receptors Reverses MK-801-Induced Behavioral Impairments and Enhances Associative Learning in Rodents
Positive allosteric modulators (PAMs) of the M4 muscarinic acetylcholine receptor (mAChR) represent a novel approach for the… Expand
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2014
2014
Effects of the M4 muscarinic receptor positive allosteric modulator VU0467154 on cognition and pyramidal cell firing properties in layer V of the mPFC (845.9)
Many symptoms in schizophrenia are attributed to alternations in normal glutamatergic signaling in the prefrontal cortex (PFC… Expand
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