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ABSTRACT The opposing action of dopamine and acetylcholine has long been known to play an important role in basal ganglia… Expand RationaleStimulating muscarinic M1/M4 receptors can blunt reinforcing and other effects of cocaine. A hallmark of addiction is… Expand BACKGROUND
Cocaine addiction is a chronic brain disease affecting neurotransmission. Muscarinic cholinergic receptors modulate… Expand Src and Fyn are two Src family kinase (SFK) members that are expressed in mammalian brains and play important roles in the… Expand Accumulating evidence suggests that selective M4 muscarinic acetylcholine receptor (mAChR) activators may offer a novel strategy… Expand Positive allosteric modulators (PAMs) of the M4 muscarinic acetylcholine receptor (mAChR) represent a novel approach for the… Expand The striatum is the main input station of the basal ganglia and is extensively involved in the modulation of motivated behavior… Expand Acetylcholine signaling through muscarinic receptors has been shown to benefit memory performance in some conditions, but pan… Expand RationaleThe mesostriatal dopamine system plays a key role in mediating the reinforcing effects of psychostimulant drugs like… Expand Previous clinical and animal studies suggest that selective activators of M1 and/or M4 muscarinic acetylcholine receptors (mAChRs… Expand