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VT-464

Known as: CYP17 Inhibitor VT-464 
An orally available non-steroidal, lyase-selective inhibitor of the steroid 17-alpha-hydroxylase/C17,20 lyase (CYP17A1 or CYP17), with potential anti… Expand
National Institutes of Health

Papers overview

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2016
2016
Cytochrome P450 17α-hydroxylase/17,20-lyase (CYP17A1) is a validated treatment target for the treatment of metastatic castration… Expand
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Review
2016
Review
2016
Since androgen signaling plays a pivotal role in the proliferation and metastasis of prostate cancer, androgen deprivation… Expand
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2015
2015
187 Background: VT-464 is an oral, non-steroidal inhibitor of CYP17-L and an antagonist of androgen receptor (AR) variants F876L… Expand
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Review
2014
Review
2014
As the first in class steroid 17α-hydroxylase/C17,20-lyase (CYP17) inhibitor, abiraterone acetate (of which the active metabolite… Expand
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Highly Cited
2014
Highly Cited
2014
VT-464 is a novel, nonsteroidal, small-molecule CYP17A1 inhibitor with 17,20-lyase selectivity. This study evaluates the… Expand
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2014
2014
The orally-active CYP17A1 inhibitor abiraterone acetate (AA) decreases adrenal and intratumoral androgen biosynthesis and is an… Expand
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Review
2013
Review
2013
Since 2010, six drugs have been approved for the treatment of castration-resistant prostate cancer, i.e., CYP17 inhibitor… Expand
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2012
2012
198 Background: CYP17 is a single protein with two distinct enzyme activities, 17 α-hydroxylase (hydroxylase) and 17,20-lyase… Expand
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2012
2012
64 Background: With the recent FDA approval of abiraterone acetate, CYP17 (17α hydroxylase/C17, 20-lyase) has become a proven… Expand
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2012
2012
198 Background: CYP17 is a single protein with two distinct enzyme activities, 17 α-hydroxylase (hydroxylase) and 17,20-lyase… Expand
Is this relevant?