VT-464

Known as: CYP17 Inhibitor VT-464 
An orally available non-steroidal, lyase-selective inhibitor of the steroid 17-alpha-hydroxylase/C17,20 lyase (CYP17A1 or CYP17), with potential anti… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2012-2016
024620122016

Papers overview

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2016
2016
Cytochrome P450 17α-hydroxylase/17,20-lyase (CYP17A1) is a validated treatment target for the treatment of metastatic castration… (More)
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Review
2016
Review
2016
The approval of abiraterone and enzalutamide for the treatment of advanced castration-resistant prostate cancer heralded a… (More)
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Review
2016
Review
2016
INTRODUCTION Prostate cancer is the most common cancer in elderly males. Regardless of the initial hormonal treatment in… (More)
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Review
2016
Review
2016
Since androgen signaling plays a pivotal role in the proliferation and metastasis of prostate cancer, androgen deprivation… (More)
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2015
2015
VT-464 is a novel, nonsteroidal, small-molecule CYP17A1 inhibitor with 17,20-lyase selectivity. This study evaluates the… (More)
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Review
2015
Review
2015
The majority of prostate cancer (PCa) cases are diagnosed as a localized disease. Definitive treatment, active surveillance or… (More)
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2014
2014
The orally-active CYP17A1 inhibitor abiraterone acetate (AA) decreases adrenal and intratumoral androgen biosynthesis and is an… (More)
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Review
2014
Review
2014
As the first in class steroid 17α-hydroxylase/C17,20-lyase (CYP17) inhibitor, abiraterone acetate (of which the active metabolite… (More)
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2012
2012
198 Background: CYP17 is a single protein with two distinct enzyme activities, 17 α-hydroxylase (hydroxylase) and 17,20-lyase… (More)
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2012
2012
64 Background: With the recent FDA approval of abiraterone acetate, CYP17 (17α hydroxylase/C17, 20-lyase) has become a proven… (More)
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