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VS-6063

 
National Institutes of Health

Papers overview

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2019
2019
OBJECTIVES KRAS mutations, which occur in approximately 25% of lung adenocarcinoma cases, represent a major unmet clinical need… Expand
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2018
2018
Docetaxel, the standard chemotherapy for metastatic castration‐resistant prostate cancer (CRPC) also enhances the survival of… Expand
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2018
2018
ABSTRACT The non-receptor cytoplasmic tyrosine kinase, Focal Adhesion Kinase (FAK) is known to play a key role in a variety of… Expand
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2017
2017
Because cancer stem cells (CSCs) have been implicated in chemo-resistance, metastasis and tumor recurrence, therapeutic targeting… Expand
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2016
2016
AbstractPurpose VS-6063 (also known as defactinib or PF-04554878) is a second-generation inhibitor of focal adhesion kinase and… Expand
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Highly Cited
2015
Highly Cited
2015
SummaryObjective VS-6063 (also known as defactinib or PF-04554878) is a second-generation inhibitor of focal adhesion kinase (FAK… Expand
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2015
2015
Malignant pleural mesothelioma (MPM) is an aggressive tumor in the lining of the lung often resulting from prior exposure to… Expand
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2014
2014
5521 Background: Defactinib (VS-6063) is an oral inhibitor of focal adhesion kinase (FAK). Blockade of FAK has been shown to… Expand
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Highly Cited
2013
Highly Cited
2013
  • Y. Kang, W. Hu, +16 authors A. Sood
  • Journal of the National Cancer Institute
  • 2013
  • Corpus ID: 21687857
BACKGROUND We previously found focal adhesion kinase (FAK) inhibition sensitizes ovarian cancer to taxanes; however, the… Expand
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2013
2013
Background: Defactinib (VS-6063) is a potent, reversible, oral inhibitor of focal adhesion kinase (FAK). Blockade of FAK reduces… Expand
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