VPS36 gene

Known as: ELL-ASSOCIATED PROTEIN, 45-KD, EAP45, VACUOLAR PROTEIN SORTING 36, S. CEREVISIAE, HOMOLOG OF 
 
National Institutes of Health

Papers overview

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2008
2008
Integrated structural model and membrane targeting mechanism of the human ESCRT-II complex.
ESCRT-II plays a pivotal role in receptor downregulation and multivesicular body biogenesis and is conserved from yeast to humans… Expand
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Highly Cited
2007
Highly Cited
2007
bicoid RNA localization requires specific binding of an endosomal sorting complex
bicoid messenger RNA localizes to the anterior of the Drosophila egg, where it is translated to form a morphogen gradient of… Expand
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Highly Cited
2007
Highly Cited
2007
RILP is required for the proper morphology and function of late endosomes.
Lysosomal degradation of signalling receptors such as the epidermal growth factor (EGF) receptor (EGFR) is an important mechanism… Expand
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2006
2006
Structural basis of ubiquitin recognition by mammalian Eap45 GLUE domain
ESCRT-II, a complex that sorts ubiquitinated membrane proteins to lysosomes, localizes to endosomes through interaction between… Expand
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2006
2006
Structural basis for ubiquitin recognition by the human ESCRT-II EAP45 GLUE domain
The ESCRT-I and ESCRT-II complexes help sort ubiquitinated proteins into vesicles that accumulate within multivesicular bodies… Expand
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2006
2006
RILP interacts with VPS22 and VPS36 of ESCRT-II and regulates their membrane recruitment.
RILP is emerging as a key regulator of late endocytic pathway by functioning as a downstream effector of activated Rab7 and Rab34… Expand
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Highly Cited
2006
Highly Cited
2006
Human ESCRT-II complex and its role in human immunodeficiency virus type 1 release.
The budding of many enveloped RNA viruses, including human immunodeficiency virus type 1 (HIV-1), requires some of the same… Expand
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Highly Cited
2005
Highly Cited
2005
Eap45 in mammalian ESCRT-II binds ubiquitin via a phosphoinositide-interacting GLUE domain.
Ubiquitination serves as a key sorting signal in the lysosomal degradation of endocytosed receptors through the ability of… Expand
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2005
2005
Components of the ESCRT pathway, DFG16, and YGR122w are required for Rim101 to act as a corepressor with Nrg1 at the negative regulatory element of the DIT1 gene of Saccharomyces cerevisiae.
The divergently transcribed DIT1 and DIT2 genes of Saccharomyces cerevisiae, which belong to the mid-late class of sporulation… Expand
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Highly Cited
2004
Highly Cited
2004
ESCRT-II, an endosome-associated complex required for protein sorting: crystal structure and interactions with ESCRT-III and membranes.
ESCRT-I, -II, and -III protein complexes are sequentially recruited to endosomal membranes, where they orchestrate protein… Expand
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