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VE 821

Known as: VE-821, VE821 cpd 
National Institutes of Health

Papers overview

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2019
2019
ATR kinase inhibition sensitizes quiescent human cells to the lethal effects of cisplatin but increases mutagenesis.
2018
2018
Small Molecules Identified from a Quantitative Drug Combinational Screen Resensitize Cisplatin's Response in Drug-Resistant Ovarian Cancer Cells
2017
2017
Evaluation of [18F]-ATRi as PET tracer for in vivo imaging of ATR in mouse models of brain cancer.
2017
2017
Spliceosomal Mutations Induce R Loop-Associated ATR Signaling
Recurrent missense mutations in genes encoding RNA splicing factors (e.g. U2AF1, SRSF2 and SF3B1) are among the most frequently… 
2016
2016
Comparison of the Radiosensitizing Effect of ATR, ATM and DNA-PK Kinase Inhibitors on Cervical Carcinoma Cells.
Here, we compared the effects of inhibitors of three phosphatidylinositol-3-kinase-related kinases, ATM, ATR a DNA-PK, on… 
2016
2016
Synergistic potentiation of (-)-lomaiviticin A cytotoxicity by the ATR inhibitor VE-821.
2015
2015
VE-821, an ATR inhibitor, causes radiosensitization in human tumor cells irradiated with high LET radiation
High linear energy transfer (LET) radiation such as carbon ion particles is successfully used for treatment of solid tumors. The… 
2015
2015
Abstract 5327: Simultaneous inhibition of ATR and PARP greatly sensitizes colon cancer cell lines to irinotecan
Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA Enhanced DNA damage repair is one mechanism… 
2014
2014
Abstract 2418: Investigating p53 and other potential determinants of cell sensitivity to ATR inhibition by VE-821
Proceedings: AACR Annual Meeting 2014; April 5-9, 2014; San Diego, CA Background: Defects in the multifactorial DNA damage… 
2013
2013
Abstract 4476: Cytotoxicity of a novel bi-functional temozolomide analog, DP68, is independent of MGMT status in glioblastoma models.
Resistance to temozolomide (TMZ) in the majority of glioblastoma multiforme (GBM) is mediated by O6-methylguanine… 
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