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VAS203

National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Efficacy of Ronopterin (VAS203) in Patients with Moderate and Severe Traumatic Brain Injury (NOSTRA phase III trial): study protocol of a confirmatory, placebo-controlled, randomised, double blind…
Background Traumatic brain injury is a leading cause of death and disability worldwide. The nitric oxide synthase inhibitor… Expand
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2020
2020
Correction to: Efficacy of Ronopterin (VAS203) in Patients with Moderate and Severe Traumatic Brain Injury (NOSTRA phase III trial): study protocol of a confirmatory, placebocontrolled, randomised…
After publication of our article [1] the authors have notified us that one of the names has been incorrectly spelled. 
2019
2019
Effects of the nitric oxide synthase inhibitor ronopterin (VAS203) on renal function in healthy volunteers
Reduced nitric oxide (NO) availability may adversely affect renal perfusion and glomerular filtration. The aim of the present… Expand
2017
2017
Nitric Oxide Synthase Inhibitors in Traumatic Brain Injury
Abstract In the complex pathophysiology of traumatic brain injury (TBI), nitric oxide (NO) is one of the key molecules with both… Expand
Review
2016
Review
2016
Pharmacologic Neuroprotection for Functional Outcomes After Traumatic Brain Injury: A Systematic Review of the Clinical Literature
IntroductionTraumatic brain injury (TBI) is a major cause of death and disability worldwide. The deleterious effects of secondary… Expand
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2015
2015
Endothelial nitric oxide synthase mediates arteriolar vasodilatation after traumatic brain injury in mice.
Brain edema and increased cerebral blood volume (CBV) contribute to intracranial hypertension and hence to unfavorable outcome… Expand
2014
2014
Nitric oxide synthase inhibition with the antipterin VAS203 improves outcome in moderate and severe traumatic brain injury: a placebo-controlled randomized Phase IIa trial (NOSTRA).
Abstract Traumatic brain injury (TBI) is an important cause of death and disability. Safety and pharmacodynamics of 4-amino… Expand
2014
2014
Nitric oxide synthase inhibition with the antipterin VAS203 improves outcome in moderate and severe traumatic brain injury: a placebo-controlled randomized Phase IIa trial (NOSTRA).
Traumatic brain injury (TBI) is an important cause of death and disability. Safety and pharmacodynamics of 4-amino… Expand
2009
2009
The novel nitric oxide synthase inhibitor 4-amino-tetrahydro-L-biopterine prevents brain edema formation and intracranial hypertension following traumatic brain injury in mice.
Brain edema formation, resulting in increased intracranial pressure (ICP), is one of the most deleterious consequences of… Expand
2009
2009
The Novel Nitric Oxide Synthase Inhibitor 4-amino-tetrahydro-L-biopterine Prevents Brain Edema Formation and Intracranial Hypertension following Traumatic Brain Injury in Mice
Abstract Brain edema formation, resulting in increased intracranial pressure (ICP), is one of the most deleterious consequences… Expand
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