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VAC14 gene

Known as: ArPIKfyve, ASSOCIATED REGULATOR OF PIKFYVE, VAC14, S. CEREVISIAE, HOMOLOG OF 
National Institutes of Health

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VAC14 protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
VAC14 syndrome in two siblings with retinitis pigmentosa and neurodegeneration with brain iron accumulation
Whole-exome sequencing was used to identify the genetic etiology of a rapidly progressing neurological disease present in two of… 
2019
2019
Novel VAC14 variants identified in two Chinese siblings with childhood‐onset striatonigral degeneration
VAC14 is a component of a trimolecular complex that tightly regulates the level of phosphatidylinositol 3,5‐bisphosphate [PI (3,5… 
Review
2019
Review
2019
Homozygous variant, p.(Arg643Trp) in VAC14 causes striatonigral degeneration: report of a novel variant and review of VAC14-related disorders
VAC14-related disorders include two distinct phenotypes, striatonigral degeneration [MIM# 617054] and Yunis–Varon syndrome… 
2018
2018
Arabidopsis VAC14 Is Critical for Pollen Development through Mediating Vacuolar Organization1[OPEN]
Arabidopsis thaliana VAC14 is critical for pollen development likely by mediating the production of PI(3,5)P2 to regulate dynamic… 
2013
2013
The PIKfyve-ArPIKfyve-Sac3 triad in human breast cancer: Functional link between elevated Sac3 phosphatase and enhanced proliferation of triple negative cell lines.
2010
2010
ArPIKfyve Regulates Sac3 Protein Abundance and Turnover
The mammalian phosphatidylinositol (3,5)-bisphosphate (PtdIns(3,5)P2) phosphatase Sac3 and ArPIKfyve, the associated regulator of… 
2009
2009
PIKfyve-ArPIKfyve-Sac3 Core Complex
The phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) metabolizing enzymes, the kinase PIKfyve and the phosphatase Sac3… 
Highly Cited
2008
Highly Cited
2008
ArPIKfyve homomeric and heteromeric interactions scaffold PIKfyve and Sac3 in a complex to promote PIKfyve activity and functionality.
Highly Cited
2007
Highly Cited
2007
ArPIKfyve-PIKfyve interaction and role in insulin-regulated GLUT4 translocation and glucose transport in 3T3-L1 adipocytes.
Highly Cited
2004
Highly Cited
2004
A Mammalian Ortholog of Saccharomyces cerevisiae Vac14 That Associates with and Up-Regulates PIKfyve Phosphoinositide 5-Kinase Activity
ABSTRACT Multivesicular body morphology and size are controlled in part by PtdIns(3,5)P2, produced in mammalian cells by PIKfyve… 
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