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URMC-099

National Institutes of Health

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Papers overview

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2018
2018
URMC-099 facilitates amyloid-β clearance in a murine model of Alzheimer’s disease
The mixed lineage kinase type 3 inhibitor URMC-099 facilitates amyloid-beta (Aβ) clearance and degradation in cultured murine… 
2016
2016
The mixed lineage kinase-3 inhibitor URMC-099 improves therapeutic outcomes for long-acting antiretroviral therapy.
2016
2016
The mixed-lineage kinase 3 inhibitor URMC-099 facilitates microglial amyloid-β degradation
Amyloid-β (Aβ)-stimulated microglial inflammatory responses engage mitogen-activated protein kinase (MAPK) pathways in Alzheimer… 
2016
2016
Correction: Mixed lineage kinase 3 mediates release of C-X-C motif ligand 10-bearing chemotactic extracellular vesicles from lipotoxic hepatocytes.
C-X-C Motif Ligand 10–Bearing Chemotactic Extracellular Vesicles From Lipotoxic Hepatocytes” (volume 63, pages 731-734; doi: 10… 
2013
2013
URMC-099, a Novel Kinase Inhibitor with Drug-like Properties, is Neuroprotective in Models of Human Immunodeficiency Virus Associated Neurocognitive Disorders
2012
2012
Attenuation of Microglial Activation Protects Hippocampal Synapses in Experimental Autoimmune Encephalomyelitis (P05.112)
Objective: To test whether URMC-099, a novel small molecule inhibitor of fms-like tyrosine kinase 3 (FLT3) and mixed lineage… 
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