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UGT2B10 gene

Known as: UGT2B10, URIDINE DIPHOSPHATE GLYCOSYLTRANSFERASE 2 FAMILY, MEMBER B10, UDP glucuronosyltransferase family 2 member B10 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
UGT2B10 Genotype Influences Serum Cotinine Levels and Is a Primary Determinant of Higher Cotinine in African American Smokers
Background: Cotinine is the most widely used biomarker of tobacco exposure. At similar smoking levels, African Americans have… 
2018
2018
Disposition of Mianserin and Cyclizine in UGT2B10-Overexpressing Human Embryonic Kidney 293 Cells: Identification of UGT2B10 as a Novel N-Glucosidation Enzyme and Breast Cancer Resistance Protein as…
UDP-glucuronosyltransferases (UGTs) play an important role in the metabolism and detoxification of amine-containing chemicals… 
2018
2018
Highly selective N-glucuronidation of four piperazine-containing drugs by UDP-glucuronosyltransferase 2B10
ABSTRACT Background: N-glucuronidation is known to be an important metabolic pathway for detoxification and elimination of drugs… 
2017
2017
Low Cotinine Glucuronidation Results in Higher Serum and Saliva Cotinine in African American Compared to White Smokers
Background: Tobacco exposure is often quantified by serum or saliva concentrations of the primary nicotine metabolite, cotinine… 
2012
2012
Abstract 268: Regulation of the UDP-glucuronosyltransferases (UGTs) by UV exposure in human melanocytes
Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL The UDP-glucuronosyltransferase (UGT) family of… 
2011
2011
Olanzapine metabolism and the significance of UGT1A448V and UGT2B1067Y variants
Objectives Olanzapine is an antipsychotic used in the treatment of schizophrenia, bipolar disorder, and treatment-resistant… 
2010
2010
UGT2B10 Genotype Influences Nicotine Glucuronidation, Oxidation, and Consumption
Background: Tobacco exposure is routinely assessed by quantifying nicotine metabolites in plasma or urine. On average, 80% of… 
2010
2010
Abstract 918: Glucuronidation genotypes and nicotine metabolic phenotypes: Importance of UGT2B10 and UGT2B17 knock-out polymorphisms
Glucuronidation is an important pathway in the metabolism of nicotine, with ∼28% of urinary nicotine metabolites in the form of… 
Highly Cited
2008
Highly Cited
2008
Identification of a prevalent functional missense polymorphism in the UGT2B10 gene and its association with UGT2B10 inactivation against tobacco-specific nitrosamines
Objective To study the potential association between UDP-glucuronosyltransferase (UGT)2B10 genotypes and [4-(methylnitrosamino)-1… 
Highly Cited
2007
Highly Cited
2007
Glucuronidation of nicotine and cotinine by UGT2B10: loss of function by the UGT2B10 Codon 67 (Asp>Tyr) polymorphism.
Nicotine, the major addicting agent in tobacco and tobacco smoke, undergoes a complex metabolic pathway, with approximately 22… 
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