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UC-961

National Institutes of Health

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Cirmtuzumab

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Abstract 1193: Treatment of breast cancer xenografts with paclitaxel enriches for cancer stem cells that can be targeted by a ROR1-specific antibody
Although initially responsive to hormone therapy and chemotherapy, many patients with metastatic breast cancer develop resistant… 
2015
2015
Cirmtuzumab (UC-961), a First-in-Class Anti-ROR1 Monoclonal Antibody: Planned Interim Analysis of Initial Phase 1 Cohorts
INTRODUCTION: Chronic lymphocytic leukemia (CLL) cells of nearly all patients (pts) express ROR1 (Receptor tyrosine kinase-like… 
2015
2015
Structural Features of ROR1 Required for Complexing with ROR2 and Enhancing Chemokine-Induced Migration and Leukemia-Cell Proliferation, Which Can be Blocked By the Anti-ROR1 Mab Cirmtuzumab (UC-961)
Evolutionarily-conserved ROR1 and ROR2 are each considered a distinct receptor for Wnt5a, implicated in non-canonical Wnt… 
2014
2014
Abstract 206: Depletion of ovarian cancer initiating cells by a monoclonal antibody against ROR1
ROR1 is a type I orphan-receptor tyrosine-kinase-like surface protein that is expressed during embryogenesis and by various… 
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