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Inhibition of protein-protein interactions by small molecules offers tremendous opportunities for basic research and drug… Expand The study of Drosophila Hox genes, located in the Antennapedia complex (ANT-C) and Bithorax complex (BX-C), has provided… Expand Mutations in ATP13A2 (PARK9) have been linked to juvenile parkinsonism with dementia or Kufor-Rakeb syndrome (KRS). The ATP13A2… Expand Loss of ubiquilin or erasin activates ER stress, increases accumulation of polyubiquitinated proteins, and shortens lifespan in… Expand Ubiquitin regulator-X (UBX) is a discrete protein domain that binds p97/valosin-containing protein (VCP), a molecular chaperone… Expand Homeotic (Hox) genes code for principal transcriptional regulators of animal body regionalization. The duplication and divergence… Expand The Hox genes have been implicated as central to the evolution of animal body plan diversity. Regulatory changes both in Hox… Expand Genetic variation affecting the expressivity of an amorphic allele of the homeotic gene Ultrabithorax, (Ubx1) was characterized… Expand Homeotic genes encode DNA-binding transcription factors that specify the identity of a segment or segments in particular body… Expand The Drosophila homeotic gene Ultrabithorax (Ubx) encodes transcriptional regulatory proteins (UBX) that specify thoracic and… Expand