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UBR1 gene

Known as: UBIQUITIN-PROTEIN LIGASE E3 COMPONENT N-RECOGNIN 1, UBR1, ubiquitin protein ligase E3 component n-recognin 1 
 
National Institutes of Health

Papers overview

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2016
2016
Most misfolded cytosolic proteins in the cell are eliminated by the ubiquitin–proteasome system. In yeast, polyubiquitination of… Expand
2014
2014
Protein degradation in eukaryotic cells is mediated mainly by the ubiquitin (Ub)-proteasome system. One fundamental question in… Expand
2012
2012
Mutations causing protein misfolding and proteolysis are associated with many genetic diseases. The degradation of these aberrant… Expand
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2011
2011
Background Johanson-Blizzard syndrome (JBS; OMIM 243800) is an autosomal recessive disorder that includes congenital exocrine… Expand
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Highly Cited
2010
Highly Cited
2010
Substrates of the N-end rule pathway are recognized by the Ubr1 E3 ubiquitin ligase through their destabilizing amino-terminal… Expand
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Highly Cited
2010
Highly Cited
2010
Ubr1 and Ubr2 ubiquitin ligases are shown to promote degradation of misfolded cytosolic polypeptides in vivo and in a purified… Expand
2010
2010
Of 20 natural amino acids, leucine is particularly important for promoting cellular protein synthesis. The effect of leucine… Expand
Highly Cited
2009
Highly Cited
2009
Eukaryotic cells maintain proteostasis by quality control (QC) degradation. These pathways can specifically target a wide variety… Expand
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2008
2008
Substrates of the N-end rule pathway include proteins with destabilizing N-terminal residues. These residues are recognized by E3… Expand
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2002
2002
The N‐end rule pathway, a subset of the ubiquitin pathway, relates the in vivo half‐life of a protein to the identity of its N… Expand