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UBR1 gene

Known as: UBIQUITIN-PROTEIN LIGASE E3 COMPONENT N-RECOGNIN 1, UBR1, ubiquitin protein ligase E3 component n-recognin 1 
 
National Institutes of Health

Papers overview

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2014
2014
Protein degradation in eukaryotic cells is mediated mainly by the ubiquitin (Ub)-proteasome system. One fundamental question in… Expand
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2013
2013
The UBR1 ubiquitin ligase promotes degradation of proteins via the N-end rule and by another mechanism that detects a misfolded… Expand
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2012
2012
Mutations causing protein misfolding and proteolysis are associated with many genetic diseases. The degradation of these aberrant… Expand
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2011
2011
BACKGROUND Johanson-Blizzard syndrome (JBS; OMIM 243800) is an autosomal recessive disorder that includes congenital exocrine… Expand
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Highly Cited
2010
Highly Cited
2010
Eukaryotic cells maintain proteostasis by quality control (QC) degradation. These pathways can specifically target a wide variety… Expand
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Highly Cited
2010
Highly Cited
2010
Substrates of the N-end rule pathway are recognized by the Ubr1 E3 ubiquitin ligase through their destabilizing amino-terminal… Expand
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Highly Cited
2010
Highly Cited
2010
Quality control systems facilitate polypeptide folding and degradation to maintain protein homeostasis. Molecular chaperones… Expand
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2010
2010
Of 20 natural amino acids, leucine is particularly important for promoting cellular protein synthesis. The effect of leucine… Expand
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2008
2008
Substrates of the N-end rule pathway include proteins with destabilizing N-terminal residues. These residues are recognized by E3… Expand
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2002
2002
The N-end rule pathway, a subset of the ubiquitin pathway, relates the in vivo half-life of a protein to the identity of its N… Expand
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