UBE2T, IVS2DS, G-A, +5

 
National Institutes of Health

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FANCONI ANEMIA, COMPLEMENTATION GROUP T

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2019
2019
Deficiency of the Fanconi anemia E2 ubiqitin conjugase UBE2T only partially abrogates Alu-mediated recombination in a new model of homology dependent recombination
The primary function of the UBE2T ubiquitin conjugase is in the monoubiquitination of the FANCI-FANCD2 heterodimer, a central… (More)
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2018
2018
UBE2M Is a Stress-Inducible Dual E2 for Neddylation and Ubiquitylation that Promotes Targeted Degradation of UBE2F.
UBE2M and UBE2F are two family members of neddylation E2 conjugating enzyme that, together with E3s, activate CRLs (Cullin-RING… (More)
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2018
2018
A first-in-class inhibitor, MLN4924 (pevonedistat), induces cell-cycle arrest, senescence, and apoptosis in human renal cell carcinoma by suppressing UBE2M-dependent neddylation modification
PurposeMLN4924 is a second-generation inhibitor that targets ubiquitin–proteasome system by inhibiting neddylation activation… (More)
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2017
2017
UBE2T knockdown inhibits gastric cancer progression
Ubiquitin-conjugating enzymes (E2 enzymes) such as UBE2T target proteins for degradation via the proteasome. Here, we examined… (More)
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2016
2016
UBE2T promotes nasopharyngeal carcinoma cell proliferation, invasion, and metastasis by activating the AKT/GSK3β/β-catenin pathway
Increasing evidence has shown that UBE2T plays an important role in genomic integrity and carcinogenesis; however, its role in… (More)
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2009
2009
FANCI binds branched DNA and is monoubiquitinated by UBE2T-FANCL.
FANCI is integral to the Fanconi anemia (FA) pathway of DNA damage repair. Upon the occurrence of DNA damage, FANCI becomes… (More)
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Highly Cited
2006
Highly Cited
2006
UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation.
The Fanconi anemia pathway is required for the efficient repair of damaged DNA. A key step in this pathway is the… (More)
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