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UBE2L6 gene

Known as: UBIQUITIN-CONJUGATING ENZYME UBCH8, ubiquitin conjugating enzyme E2 L6, UBIQUITIN-CONJUGATING ENZYME E2L 6 
National Institutes of Health

Related topics

Related topics

1 relation
UBE2E2 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
UBE2L6/UBCH8 and ISG15 attenuate autophagy in esophageal cancer cells
Esophageal cancer remains a poor prognosis cancer due to advanced stage of presentation and drug resistant disease. To understand… 
2013
2013
Immunoproteasomes Are Important for Proteostasis in Immune Responses
2011
2011
Selective Ubiquitylation of p21 and Cdt1 by UBCH8 and UBE2G Ubiquitin-Conjugating Enzymes via the CRL4Cdt2 Ubiquitin Ligase Complex
ABSTRACT CRL4Cdt2 is a cullin-based E3 ubiquitin ligase that promotes the ubiquitin-dependent proteolysis of various substrates… 
Highly Cited
2009
Highly Cited
2009
The structure of the UbcH8-ubiquitin complex shows a unique ubiquitin interaction site.
Ubiquitin-mediated proteolysis utilizes a series of three key enzymes (E1, E2, and E3) to transfer and then covalently modify a… 
Highly Cited
2008
Highly Cited
2008
UbcH8 regulates ubiquitin and ISG15 conjugation to RIG-I.
Highly Cited
2008
Highly Cited
2008
ISG15 as a novel tumor biomarker for drug sensitivity
Tumor cells are known to exhibit highly varied sensitivity to camptothecins (CPT; e.g., irinotecan and topotecan). However, the… 
Highly Cited
2008
Highly Cited
2008
The Basis for Selective E1-E2 Interactions in the ISG15 Conjugation System*
E1 and E2 enzymes coordinate the first steps in conjugation of ubiquitin (Ub) and ubiquitin-like proteins (Ubls). ISG15 is an… 
2005
2005
Down-regulation of UCRP and UBE2L6 in BRCA2 knocked-down human breast cells.
Highly Cited
2004
Highly Cited
2004
The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-α/β-induced ubiquitin-like protein
Ubiquitin-(Ub) like proteins (Ubls) are conjugated to their targets by an enzymatic cascade involving an E1 activating enzyme, an… 
Highly Cited
2004
Highly Cited
2004
The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-alpha/beta-induced ubiquitin-like protein.
Ubiquitin-(Ub) like proteins (Ubls) are conjugated to their targets by an enzymatic cascade involving an E1 activating enzyme, an… 
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