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UBA5 gene

Known as: FLJ23251, UBIQUITIN-ACTIVATING ENZYME E1 DOMAIN-CONTAINING 1, UBA5, ubiquitin-activating enzyme E1 homolog (yeast) 
National Institutes of Health

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UBA1 gene

Papers overview

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2020
2020
An atypical LIR motif within UBA5 (ubiquitin like modifier activating enzyme 5) interacts with GABARAP proteins and mediates membrane localization of UBA5
ABSTRACT Short linear motifs, known as LC3-interacting regions (LIRs), interact with mactoautophagy/autophagy modifiers (Atg8/LC3… 
2019
2019
An N-Terminal Extension to UBA5 Adenylation Domain Boosts UFM1 Activation: Isoform-Specific Differences in Ubiquitin-like Protein Activation.
2018
2018
Trans‐binding of UFM1 to UBA5 stimulates UBA5 homodimerization and ATP binding
All ubiquitin‐like proteins (UBLs) undergo an activation process before their conjugation to target proteins. Although the steps… 
2017
2017
Novel insights into the interaction of UBA5 with UFM1 via a UFM1-interacting sequence
The modification of proteins by ubiquitin-fold modifier 1 (UFM1) is implicated in many human diseases. Prior to conjugation, UFM1… 
Review
2016
Review
2016
UFMylation: A Unique & Fashionable Modification for Life
2016
2016
Trans-Binding Mechanism of Ubiquitin-like Protein Activation Revealed by a UBA5-UFM1 Complex.
Highly Cited
2016
Highly Cited
2016
Structural and Functional Analysis of a Novel Interaction Motif within UFM1-activating Enzyme 5 (UBA5) Required for Binding to Ubiquitin-like Proteins and Ufmylation*
The covalent conjugation of ubiquitin-fold modifier 1 (UFM1) to proteins generates a signal that regulates transcription… 
2016
2016
A selective inhibitor of the UFM1-activating enzyme, UBA5.
2014
2014
Mechanistic Study of Uba5 Enzyme and the Ufm1 Conjugation Pathway
Background: Human ubiquitin-like protein Ufm1 and its activating enzyme, Uba5, are involved in endoplasmic reticulum (ER) stress… 
2014
2014
Characterization, crystallization and preliminary X-ray crystallographic analysis of the human Uba5 C-terminus-Ufc1 complex.
Human Uba5, which contains an adenylation domain and a C-terminal region, is the smallest ubiquitin-like molecule-activating… 
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