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U2AF

Known as: U2 accessory factor 
A heterodimeric protein complex consisting of conserved large and small U2AF subunits that contributes to spliceosomal RNA splicing by binding to… 
National Institutes of Health

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Broader (1)

Cell Nucleus

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2007
2007
A Conditional Role of U2AF in Splicing of Introns with Unconventional Polypyrimidine Tracts
ABSTRACT Recognition of polypyrimidine (Py) tracts typically present between the branch point and the 3′ splice site by the large… 
Highly Cited
2006
Highly Cited
2006
RNA interference knockdown of hU2AF35 impairs cell cycle progression and modulates alternative splicing of Cdc25 transcripts.
U2AF is a heterodimeric splicing factor composed of a large (U2AF65) and a small (U2AF35) subunit. In humans, alternative… 
2005
2005
Substrate-dependent Differences in U2AF Requirement for Splicing in Adenovirus-infected Cell Extracts*
U2AF has been characterized as an essential splicing factor required for efficient recruitment of U2 small nuclear… 
Highly Cited
2002
Highly Cited
2002
U2AF Participates in the Binding of TAP (NXF1) to mRNA*
TAP/NXF1 is a conserved mRNA export receptor serving as a link between messenger ribonucleoproteins (mRNPs) and the nuclear pore… 
Highly Cited
1999
Highly Cited
1999
Distinct Factor Requirements for Exonic Splicing Enhancer Function and Binding of U2AF to the Polypyrimidine Tract*
Exonic splicing enhancer (ESE) sequences are important for the recognition of adjacent splice sites in pre-mRNA and for the… 
1998
1998
A Role for SRp54 during Intron Bridging of Small Introns with Pyrimidine Tracts Upstream of the Branch Point
ABSTRACT One of the earliest steps in pre-mRNA recognition involves binding of the splicing factor U2 snRNP auxiliary factor… 
1997
1997
SC35-mediated reconstitution of splicing in U2AF-depleted nuclear extract.
Assembly of the mammalian spliceosome is known to proceed in an ordered fashion through several discrete complexes, but the… 
1997
1997
Cloning of Caenorhabditis U2AF65: an alternatively spliced RNA containing a novel exon
The U2 small nuclear ribonucleoprotein particle (snRNP) auxiliary factor, U2AF, is an essential splicing factor required for… 
1996
1996
The small subunit of the splicing factor U2AF is conserved in fission yeast.
The human splicing factor U2 auxiliary factor (hsU2AF) is comprised of two interacting subunits of 65 and 35 kDa. Previously we… 
1995
1995
Isolation and mapping of human homologues of an imprinted mouse gene U2af1-rs1.
We have isolated human homologues of the imprinted mouse gene, U2af1-rs1. Two different types of cDNAs and three distinct genomic… 
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