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U2AF

Known as: U2 accessory factor 
A heterodimeric protein complex consisting of conserved large and small U2AF subunits that contributes to spliceosomal RNA splicing by binding to… 
National Institutes of Health

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Broader (1)

Cell Nucleus

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
U2AF1 Driver Mutations in Hematopoietic Disorders Alter but Do Not Abrogate RNA Binding and Enlighten Structural Dependencies of the U2AF-RNA Complex
Among genetic aberrations responsible for ineffective hematopoiesis in myelodysplastic syndromes (MDS) and acute myeloid leukemia… 
Review
2015
Review
2015
Reflections on the RNA journal at 20 and its role in the question of splice site choice
My first response to hearing that the RNA journal was turning 20 was one of some alarm—how can that much time have gone by and so… 
2012
2012
Functional analysis of the U2AF35 family of splicing factors
Tese de doutoramento, Ciencias Biomedicas (Ciencias Funcionais), Universidade de Lisboa, Faculdade de Medicina, 2012 
2012
2012
Multiple hnRNP proteins associate with nascent pre-mRNA molecules and influence RNA metabolism from transcription to RNA decay
Joao Paulo Tavanez,1,2 Tobias Madl,4,5,6 Hamed Kooshapur,4,5 Michael Sattler,4,5 and Juan Valcárcel1,2,3,* 1Centre de Regulaci… 
2006
2006
Molecular Characterization and Phylogeny of U 2 AF 35 Homologs in Plants 1 [ W ] [ OA ]
U2AF (U2 small nuclear ribonucleoprotein auxiliary factor) is an essential splicing factor with critical roles in recognition of… 
2000
2000
Mutations in the large subunit of U2AF disrupt pre‐mRNA splicing, cell cycle progression and nuclear structure
The prp2 gene of fission yeast has previously been shown to encode the large subunit of the splicing factor spU2AF. SpU2AF59 is… 
1998
1998
Existence and localization of a protein in zebra finch brain with similar structural features as the large subunit of the splicing factor U2AF.
From brains of the adult male zebra finch, we purified a peptide that has a homologous sequence of the large subunit of human… 
1996
1996
Biochemical properties of a novel U2AF65 protein isoform generated by alternative RNA splicing.
A variety of RNA binding proteins with one or more RNA recognition (RNP-CS) motifs play essential roles in the pre-mRNA splicing… 
1991
1991
The 5' end domain of U2 snRNA is required to establish the interaction of U2 snRNP with U2 auxiliary factor(s) during mammalian spliceosome assembly.
Stable association of U2 snRNP with the branchpoint sequence of mammalian pre-mRNAs requires binding of a non-snRNP protein to… 
1991
1991
Proteolysis of splicing factors during rat and monkey cell fractionation.
We have investigated the ability of various rat and monkey cell lines to yield nuclear extracts that would allow splicing of a… 
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