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U 89678
Known as:
U-89678
National Institutes of Health
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1 relation
Broader (1)
Pregnatrienes
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
1998
1998
Induction of tirilazad clearance by phenytoin
J. Fleishaker
,
L. K. Pearson
,
G. Peters
Biopharmaceutics & drug disposition
1998
Corpus ID: 45085501
Tirilazad is a membrane lipid peroxidation inhibitor being studied for the management of subarachnoid hemorrhage; phenytoin is…
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1998
1998
Biotransformation of tirilazad in human: 4. effect of finasteride on tirilazad clearance and reduced metabolite formation.
J. Fleishaker
,
P. G. Pearson
,
L. Wienkers
,
L. K. Pearson
,
T. Moore
,
G. Peters
Journal of Pharmacology and Experimental…
1998
Corpus ID: 14041808
The effect of oral finasteride, an inhibitor of 5alpha-reductase, on the clearance of tirilazad, a membrane lipid peroxidation…
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1998
1998
Biotransformation of tirilazad in human: 3. tirilazad A-ring reduction by human liver microsomal 5alpha-reductase type 1 and type 2.
L. Wienkers
,
R. Steenwyk
,
M. J. Hauer
,
J. Fleishaker
,
P. Pearson
Journal of Pharmacology and Experimental…
1998
Corpus ID: 29511162
Tirilazad mesylate (FREEDOX), a potent inhibitor of membrane lipid peroxidation in vitro, is under clinical development for the…
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1997
1997
Pharmacokinetics of tirilazad and U-89678, an active, reduced metabolite, following acute head trauma in adults.
J. Fleishaker
,
R. N. Straw
,
C. J. Cross
Journal of Pharmacy and Science
1997
Corpus ID: 27359171
The pharmacokinetics of tirilazad and U-89678 (an active metabolite) were evaluated in 55 adults (48 males, 7 females) with…
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Highly Cited
1996
Highly Cited
1996
Protective effects of tirilazad mesylate and metabolite U-89678 against blood-brain barrier damage after subarachnoid hemorrhage and lipid peroxidative neuronal injury.
S. L. Smith
,
H. M. Scherch
,
E. Hall
Journal of Neurosurgery
1996
Corpus ID: 25083880
The 21-aminosteroid lipid-peroxidation inhibitor, tirilazad mesylate (U-74006F), recently was shown in a large multinational…
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1996
1996
Biotransformation of tirilazad in human: 2. Effect of ketoconazole on tirilazad clearance and oral bioavailability.
J. Fleishaker
,
P. G. Pearson
,
L. Wienkers
,
L. K. Pearson
,
G. Peters
Journal of Pharmacology and Experimental…
1996
Corpus ID: 24822833
The effect of ketoconazole, a CYP3A inhibitor, on the oral bioavailability of tirilazad mesylate was assessed in 12 healthy…
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1996
1996
Pharmacokinetics of Tirilazad and U‐89678 in Ischemic Stroke Patients Receiving a Loading Regimen and Maintenance Regimen of 10 mg/kg/day of Tirilazad
J. Fleishaker
,
G. Peters
Journal of clinical pharmacology
1996
Corpus ID: 21881539
The pharmacokinetics of tirilazad mesylate and its active reduced metabolite, U‐89678, were evaluated in ischemic stroke patients…
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1996
1996
Gender does not affect the degree of induction of tirilazad clearance by phenobarbital
J. Fleishaker
,
L. K. Pearson
,
G. Peters
European Journal of Clinical Pharmacology
1996
Corpus ID: 10245899
Abstract.Objective: Tirilazad mesylate is a membrane lipid peroxidation inhibitor being evaluated for the treatment of patients…
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1995
1995
Effect of Gender and Menopausal Status on the Pharmacokinetics of Tirilazad Mesylate in Healthy Subjects.
J. Fleishaker
,
Laura K. Hulst-Pearson
,
G. Peters
American Journal of Therapeutics
1995
Corpus ID: 11688021
The pharmacokinetics of tirilazad were assessed in men ages 40--60 years, women <40 years of age, premenopausal women ages 40--60…
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1994
1994
The effect of phenytoin on the pharmacokinetics of tirilazad mesylate in healthy male volunteers
J. Fleishaker
,
L. K. Hulst
,
G. Peters
Clinical pharmacology and therapy
1994
Corpus ID: 1667485
The pharmacokinetic interaction between phenytoin and tirilazad was studied in 12 healthy men who received 200 mg phenytoin…
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