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U 89678

Known as: U-89678 
 
National Institutes of Health

Papers overview

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1998
1998
Tirilazad is a membrane lipid peroxidation inhibitor being studied for the management of subarachnoid hemorrhage; phenytoin is… Expand
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1998
1998
The effect of oral finasteride, an inhibitor of 5alpha-reductase, on the clearance of tirilazad, a membrane lipid peroxidation… Expand
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1998
1998
Tirilazad mesylate (FREEDOX), a potent inhibitor of membrane lipid peroxidation in vitro, is under clinical development for the… Expand
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1997
1997
The pharmacokinetics of tirilazad and U-89678 (an active metabolite) were evaluated in 55 adults (48 males, 7 females) with… Expand
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Highly Cited
1996
Highly Cited
1996
The 21-aminosteroid lipid-peroxidation inhibitor, tirilazad mesylate (U-74006F), recently was shown in a large multinational… Expand
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1996
1996
The effect of ketoconazole, a CYP3A inhibitor, on the oral bioavailability of tirilazad mesylate was assessed in 12 healthy… Expand
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1996
1996
The pharmacokinetics of tirilazad mesylate and its active reduced metabolite, U‐89678, were evaluated in ischemic stroke patients… Expand
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1996
1996
Abstract.Objective: Tirilazad mesylate is a membrane lipid peroxidation inhibitor being evaluated for the treatment of patients… Expand
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1995
1995
The pharmacokinetics of tirilazad were assessed in men ages 40--60 years, women <40 years of age, premenopausal women ages 40--60… Expand
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1994
1994
The pharmacokinetic interaction between phenytoin and tirilazad was studied in 12 healthy men who received 200 mg phenytoin… Expand
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