Skip to search formSkip to main contentSkip to account menu

U 18666A

Known as: U 18,666A, U18666A, U-18666A 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
Identification of NPC1 as the target of U18666A, an inhibitor of lysosomal cholesterol export and Ebola infection
Niemann‐Pick C1 (NPC1) is a lysosomal membrane protein that exports cholesterol derived from receptor‐mediated uptake of LDL, and… 
Review
2009
Review
2009
Cholesterol Synthesis Inhibitor U18666A and the Role of Sterol Metabolism and Trafficking in Numerous Pathophysiological Processes
The multiple actions of U18666A have enabled major discoveries in lipid research and contributed to understanding the… 
Highly Cited
2007
Highly Cited
2007
Autophagy in Niemann-Pick C disease is dependent upon Beclin-1 and responsive to lipid trafficking defects.
Niemann-Pick C (NPC) disease is an autosomal recessive lipid storage disorder characterized by a disruption of sphingolipid and… 
Highly Cited
2004
Highly Cited
2004
Accumulation of Glycosphingolipids in Niemann-Pick C Disease Disrupts Endosomal Transport*
Glycosphingolipids are endocytosed and targeted to the Golgi apparatus but are mistargeted to lysosomes in sphingolipid storage… 
Highly Cited
2002
Highly Cited
2002
ABCA1-mediated Cholesterol Efflux Is Defective in Free Cholesterol-loaded Macrophages
In advanced atherosclerosis, macrophage foam cells progressively accumulate large amounts of unesterified or “free” cholesterol… 
Highly Cited
2001
Highly Cited
2001
Accumulation of cholera toxin and GM1 ganglioside in the early endosome of Niemann–Pick C1-deficient cells
We investigated intracellular trafficking of GM1 ganglioside in Niemann–Pick C1 (NPC1)-deficient Chinese hamster ovary cells… 
Highly Cited
2000
Highly Cited
2000
The tetraspanin CD63/lamp3 cycles between endocytic and secretory compartments in human endothelial cells.
In the present study, we show that in human endothelial cells the tetraspanin CD63/lamp3 distributes predominantly to the… 
Highly Cited
2000
Highly Cited
2000
Cholesterol Movement in Niemann-Pick Type C Cells and in Cells Treated with Amphiphiles*
Cholesterol accumulates to massive levels in cells from Niemann-Pick type C (NP-C) patients and in cells treated with class 2… 
Highly Cited
1995
Highly Cited
1995
Cell Toxicity Induced by Inhibition of Acyl Coenzyme A:Cholesterol Acyltransferase and Accumulation of Unesterified Cholesterol *
Considerable evidence supports the involvement of acyl-CoA:cholesterol acyltransferase (ACAT) in the maintenance of intracellular… 
Highly Cited
1992
Highly Cited
1992
Progesterone blocks cholesterol translocation from lysosomes.
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)