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U 18666A

Known as: U 18,666A, U18666A, U-18666A 
 
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
Niemann-Pick C1 (NPC1) is a lysosomal membrane protein that exports cholesterol derived from receptor-mediated uptake of LDL, and… Expand
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Highly Cited
2007
Highly Cited
2007
Niemann-Pick C (NPC) disease is an autosomal recessive lipid storage disorder characterized by a disruption of sphingolipid and… Expand
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Highly Cited
2004
Highly Cited
2004
Glycosphingolipids are endocytosed and targeted to the Golgi apparatus but are mistargeted to lysosomes in sphingolipid storage… Expand
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Highly Cited
2002
Highly Cited
2002
In advanced atherosclerosis, macrophage foam cells progressively accumulate large amounts of unesterified or “free” cholesterol… Expand
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Highly Cited
2001
Highly Cited
2001
People homozygous for mutations in the Niemann-Pick type C1 (NPC1) gene have physiological defects, including excess accumulation… Expand
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Highly Cited
2000
Highly Cited
2000
In the present study, we show that in human endothelial cells the tetraspanin CD63/lamp3 distributes predominantly to the… Expand
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Highly Cited
2000
Highly Cited
2000
Cholesterol accumulates to massive levels in cells from Niemann-Pick type C (NP-C) patients and in cells treated with class 2… Expand
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Highly Cited
1999
Highly Cited
1999
The abundance of cell cholesterol is governed by multiple regulatory proteins in the endoplasmic reticulum (ER) which, in turn… Expand
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Highly Cited
1999
Highly Cited
1999
Niemann-Pick type C (NPC) disease is a severe cell lipidosis characterized by the accumulation of unesterified cholesterol in the… Expand
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Highly Cited
1995
Highly Cited
1995
Considerable evidence supports the involvement of acyl-CoA:cholesterol acyltransferase (ACAT) in the maintenance of intracellular… Expand
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