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Type 2 Cystatins

Known as: Cystatins, Type 2, Cystatins, Type II, Type II Cystatins 
Cystatins that occur primarily as extracellular proteins.
National Institutes of Health

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Cystatins

Papers overview

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2017
2017
Low-level internalization of cystatin E/M affects legumain activity and migration of melanoma cells
The ratio between proteases and their inhibitors is unbalanced in cancer. The cysteine protease inhibitor cystatin C is… 
2014
2014
A 170kDa multi-domain cystatin of Fasciola gigantica is active in the male reproductive system.
2013
2013
Sequence characterization and immunogenicity of cystatins from the cattle tick Rhipicephalus (Boophilus) microplus.
Review
2011
Review
2011
Cystatins of parasitic organisms.
The cystatin superfamily comprises several groups of protease inhibitors. In this chapter we will focus on I25 family members… 
Review
2010
Review
2010
Cystatins--Extra- and intracellular cysteine protease inhibitors: High-level secretion and uptake of cystatin C in human neuroblastoma cells.
2007
2007
Down-regulation of human extracellular cysteine protease inhibitors by the secreted staphylococcal cysteine proteases, staphopain A and B
Abstract Of seven human cystatins investigated, none inhibited the cysteine proteases staphopain A and B secreted by the human… 
2003
2003
Cystatins C, E/M and F in Human Pleural Fluids of Patients with Neoplastic and Inflammatory Lung Disorders
Abstract Secretory type 2 cystatins, like cystatins C, E/M and F, are thought to be involved in many pathobiological processes… 
2002
2002
Isolation of the human testatin gene and analysis in patients with abnormal gonadal development.
We have previously isolated the testatin gene using a modified mRNA differential display method on RNA from developing male and… 
Highly Cited
1999
Highly Cited
1999
Inhibition of Mammalian Legumain by Some Cystatins Is Due to a Novel Second Reactive Site*
We have investigated the inhibition of the recently identified family C13 cysteine peptidase, pig legumain, by human cystatin C… 
1994
1994
Direct mapping of seven genes encoding human type 2 cystatins to a single site located at 20p11.2.
The human type 2 cystatins are encoded by a multigene family of eight to nine members. Five functional genes (CST1-CST5) and two… 
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